| Recent patents concerning targeted therapy of apoptosis resistance in pancreatic cancer. | |
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MedLine Citation:
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PMID: 21194411 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pancreatic cancer is one of the most malignant forms of cancer. Due to numerous defects of the apoptosis machinery this tumor shows a high resistance towards conventional oncological therapies. On the level of the extrinsic pathway, signal transduction is flawed by over-expression of decoy receptors but also by a dysfunctional death inducing signaling complex (DISC). The mitochondrial pathway, normally stimulated by cell stress and toxic agents is impeded by over-expression of anti-apoptotic members of the Bcl 2 protein family and the so-called inhibitor of apoptosis proteins (IAPs). To overcome the dysfunction of the apoptosis pathway, new therapeutics focus on molecular targets within the apoptosis pathway. Recently, many new treatment modalities have been reported like recombinant ligands of the cell death receptors or inhibitors of anti-apoptotic Bcl-2 members. Furthermore, various substances for the direct activation of the caspase cascade were patented and the over-expression of IAPs could be treated by binding inhibitors or using RNA interference techniques. The present review aims at giving an overview on these new treatment modalities. |
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Authors:
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Kristin Werner; Felix Rückert; Hans-Detlev Saeger; Robert Grützmann; Christian Pilarsky |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Recent patents on DNA & gene sequences Volume: 5 ISSN: 2212-3431 ISO Abbreviation: Recent Pat DNA Gene Seq Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-16 Completed Date: 2011-07-22 Revised Date: 2011-11-10 |
Medline Journal Info:
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Nlm Unique ID: 101299745 Medline TA: Recent Pat DNA Gene Seq Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 28-34 Citation Subset: IM |
Affiliation:
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Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany. kristin.werner@uniklinikum-dresden.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis* Caspases / genetics, metabolism Humans Mitochondria / metabolism, pathology Models, Biological Pancreatic Neoplasms / metabolism, pathology, therapy* Patents as Topic* Proto-Oncogene Proteins c-bcl-2 / genetics, metabolism Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-bcl-2; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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