Document Detail


Recent insights into PDGF-induced gliomagenesis.
MedLine Citation:
PMID:  19832839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gliomas are aggressive and almost incurable glial brain tumors which frequently display abnormal platelet-derived growth factor (PDGF) signaling. Evidence gained from studies on several in vivo animal models has firmly established a causal connection between aberrant PDGF signaling and the formation of some gliomas. However, only recently has significant knowledge been gained regarding crucial issues such as the glioma cell of origin and the relationship between the transforming stimulus and the cellular characteristics of the resulting tumor. Based on recent evidence, we propose that PDGF can bias cell-fate decisions, driving the acquisition of cell type-specific features by the progeny of multipotent neural progenitors, thus determining the shape and direction of the transformation path. Furthermore, recent data about the cellular mechanisms of PDGF-driven glioma progression and maintenance indicate that PDGF may be required, unexpectedly, to override cell contact inhibition and promote glioma cell infiltration rather than to stimulate cell proliferation.
Authors:
Filippo Calzolari; Paolo Malatesta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-09-25
Journal Detail:
Title:  Brain pathology (Zurich, Switzerland)     Volume:  20     ISSN:  1750-3639     ISO Abbreviation:  Brain Pathol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-04     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216781     Medline TA:  Brain Pathol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  527-38     Citation Subset:  IM    
Affiliation:
National Institute for Cancer Research (IST), IRCCS, and Department of Oncology Biology and Genetics (DOBIG), University of Genoa, Genoa, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Neoplasms / genetics,  metabolism*,  pathology*
Cell Transformation, Neoplastic / genetics,  metabolism*,  pathology*
Glioma / genetics,  metabolism*,  pathology*
Humans
Platelet-Derived Growth Factor / genetics,  physiology*
Chemical
Reg. No./Substance:
0/Platelet-Derived Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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