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Recent Developments in Neurochemical Imaging in Schizophrenia: An Update.
MedLine Citation:
PMID:  23157626     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The advent of neurochemical brain imaging methods has provided an opportunity to study the neurochemistry of the human brain in normal and abnormal development. The aim of this article is to provide an update on recent major developments in neurochemical imaging in schizophrenia research. In this concise review, we review the major findings on three neurotransmitters, namely dopamine, serotonin and glutamate. The most promising radioligand for D2/D3 neuroreceptor imaging is the agonist [11C]PHNO, with higher in vivo affinity for D3 than D2 receptors, which can be used to measure amphetamine-induced release of dopamine, and therefore a potential model of dopaminergic alterations in schizophrenia. Recent development of selective radiotracers allow imaging of the serotonin transporter (SERT) using positron emission tomography (PET) using selective tracers such as [11C]ASB. Additionally, the glutamatergic hypothesis has evolved from theory to phase III clinical trials of newer agents with novel mechanisms. With the development of newer radioligands and the in vivo application of magnetic resonance spectroscopy at relatively high magnetic field strengths, there is ample scope for further neuroimaging advances.
Authors:
Nora S Vyas; Neva H Patel; Peter Herscovitch; Basant K Puri; Rupert Lanzenberger
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  Current medicinal chemistry     Volume:  -     ISSN:  1875-533X     ISO Abbreviation:  Curr. Med. Chem.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
The Child Psychiatry Branch, National Institutes of Health, Building 10, Rm3N202, Center Drive, Bethesda, MD, 20892-1600, USA. nora.vyas@nih.gov.
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