Document Detail


Recent developments in immune activation by uric acid crystals.
MedLine Citation:
PMID:  20502971     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Uric acid crystals, the causative agent of gout, have recently gained widespread attention due to their role as a natural endogenous adjuvant. Uric acid crystals, first sensed extracellularly by membrane lipid alterations, are internalized and subsequently activate the NLRP3 inflammasome. Currently, various aspects of this particular novel pathway are poorly defined. This short review will focus on some recent discoveries regarding this simple crystalline structure and address areas requiring further investigation. The fact that uric acid crystals activate innate host defense mechanisms, triggering robust inflammation and immune activation, may lead to engineering potent adjuvants for future vaccines. Furthermore, the elucidation of uric acid's mechanism of inflammation may lay the foundation for other solid inflammatory structures such as silica, asbestos, and alum.
Authors:
Gilbert Ng; Elaine M T Chau; Yan Shi
Publication Detail:
Type:  Journal Article; Review     Date:  2010-05-26
Journal Detail:
Title:  Archivum immunologiae et therapiae experimentalis     Volume:  58     ISSN:  1661-4917     ISO Abbreviation:  Arch. Immunol. Ther. Exp. (Warsz.)     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-16     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0114365     Medline TA:  Arch Immunol Ther Exp (Warsz)     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  273-7     Citation Subset:  IM    
Affiliation:
Immunology Research Group, Department of Microbiology and Infectious Diseases, University of Calgary, 4A31 HRIC, 3330 Hospital Dr. NW, Calgary, AB, Canada. gshng@ucalgary.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Crystallization
Gout / metabolism
Humans
Immunity, Innate / immunology*
Uric Acid / chemistry,  immunology*
Chemical
Reg. No./Substance:
69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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