Document Detail


Recent advances into understanding some aspects of the structure and function of mammalian and avian lungs.
MedLine Citation:
PMID:  20687843     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent findings are reported about certain aspects of the structure and function of the mammalian and avian lungs that include (a) the architecture of the air capillaries (ACs) and the blood capillaries (BCs); (b) the pulmonary blood capillary circulatory dynamics; (c) the adaptive molecular, cellular, biochemical, compositional, and developmental characteristics of the surfactant system; (d) the mechanisms of the translocation of fine and ultrafine particles across the airway epithelial barrier; and (e) the particle-cell interactions in the pulmonary airways. In the lung of the Muscovy duck Cairina moschata, at least, the ACs are rotund structures that are interconnected by narrow cylindrical sections, while the BCs comprise segments that are almost as long as they are wide. In contrast to the mammalian pulmonary BCs, which are highly compliant, those of birds practically behave like rigid tubes. Diving pressure has been a very powerful directional selection force that has influenced phenotypic changes in surfactant composition and function in lungs of marine mammals. After nanosized particulates are deposited on the respiratory tract of healthy human subjects, some reach organs such as the brain with potentially serious health implications. Finally, in the mammalian lung, dendritic cells of the pulmonary airways are powerful agents in engulfing deposited particles, and in birds, macrophages and erythrocytes are ardent phagocytizing cellular agents. The morphology of the lung that allows it to perform different functions-including gas exchange, ventilation of the lung by being compliant, defense, and secretion of important pharmacological factors-is reflected in its "compromise design."
Authors:
J N Maina; J B West; S Orgeig; N J Foot; C B Daniels; S G Kiama; P Gehr; C Mühlfeld; F Blank; L Müller; A Lehmann; C Brandenberger; B Rothen-Rutishauser
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Physiological and biochemical zoology : PBZ     Volume:  83     ISSN:  1537-5293     ISO Abbreviation:  Physiol. Biochem. Zool.     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-08-20     Completed Date:  2010-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883369     Medline TA:  Physiol Biochem Zool     Country:  United States    
Other Details:
Languages:  eng     Pagination:  792-807     Citation Subset:  IM    
Affiliation:
Department of Zoology, University of Johannesburg, Johannesburg, South Africa. jmaina@uj.ac.za
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MeSH Terms
Descriptor/Qualifier:
Animals
Birds*
Blood-Air Barrier / physiology*
Capillaries / cytology,  physiology*
Hemodynamics / physiology*
Humans
Lung / anatomy & histology*,  physiology*
Mammals*
Physiology, Comparative
Regional Blood Flow / physiology*
Grant Support
ID/Acronym/Agency:
R01 HL 60968/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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