Document Detail


Recent advances in the imaging of frontotemporal dementia.
MedLine Citation:
PMID:  23015371     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuroimaging has played an important role in the characterization of the frontotemporal dementia (FTD) syndromes, demonstrating neurodegenerative signatures that can aid in the differentiation of FTD from other neurodegenerative disorders. Recent advances have been driven largely by the refinement of the clinical syndromes that underlie FTD, and by the discovery of new genetic and pathological features associated with FTD. Many new imaging techniques and modalities are also now available that allow the assessment of other aspects of brain structure and function, such as diffusion tensor imaging and resting-state functional MRI. Studies have used these recent techniques, as well as traditional volumetric MRI, to provide further insight into disease progression across the many clinical, genetic, and pathological variants of FTD. Importantly, neuroimaging signatures have been identified that will improve the clinician's ability to predict underlying genetic and pathological features, and hence ultimately improve patient diagnosis.
Authors:
Jennifer L Whitwell; Keith A Josephs
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  12     ISSN:  1534-6293     ISO Abbreviation:  Curr Neurol Neurosci Rep     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2013-04-12     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  715-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Brain / pathology*,  physiopathology*
Frontotemporal Dementia / diagnosis,  genetics,  pathology*,  physiopathology*
Humans
Neuroimaging / methods,  psychology*
Grant Support
ID/Acronym/Agency:
R01 DC010367/DC/NIDCD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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