Document Detail


Recent advances and future perspectives of triazole analogs as promising antiviral agents.
MedLine Citation:
PMID:  21034403     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Emergence of severe viral infections in recent years and limited availability of antiviral chemotherapeutic agents for prevention and treatment of these infections are among the most common causes of human illness and death. Therefore, there is an urgent need to develop antiviral drugs that have a potentially critical role in the prevention and treatment of various fatal and debilitating viral infections. Triazole derivatives occupy a pivotal position in modern medicinal chemistry and several have found applications as medicines. A large volume of research has been carried out on triazole and their derivatives for antiviral activity and pharmacological importance of this scaffold has been well established. This review is primarily addressed to description of the recent advances in the synthesis and evaluation of triazole derivatives as antiviral agents which may facilitate the development of more potent and effective antiviral agents.
Authors:
Rajeev Kharb; Mohammad Shahar Yar; Prabodh Chander Sharma
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  11     ISSN:  1875-5607     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  84-96     Citation Subset:  IM    
Affiliation:
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, India. sharma_prabodh@rediffmail.com.
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