Document Detail


Receiver domain structure and function in response regulator proteins.
MedLine Citation:
PMID:  20211578     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During signal transduction by two-component regulatory systems, sensor kinases detect and encode input information while response regulators (RRs) control output. Most receiver domains function as phosphorylation-mediated switches within RRs, but some transfer phosphoryl groups in multistep phosphorelays. Conserved features of receiver domain amino acid sequence correlate with structure and hence function. Receiver domains catalyze their own phosphorylation and dephosphorylation in reactions requiring a divalent cation. Molecular dynamics simulations are supplementing structural investigation of the conformational changes that underlie receiver domain switch function. As understanding of features shared by all receiver domains matures, factors conferring differences (e.g. in reaction rate or specificity) are receiving increased attention. Numerous examples of atypical receiver or pseudo-receiver domains that function without phosphorylation have recently been characterized.
Authors:
Robert B Bourret
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-03-06
Journal Detail:
Title:  Current opinion in microbiology     Volume:  13     ISSN:  1879-0364     ISO Abbreviation:  Curr. Opin. Microbiol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-30     Completed Date:  2010-07-07     Revised Date:  2011-07-27    
Medline Journal Info:
Nlm Unique ID:  9815056     Medline TA:  Curr Opin Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  142-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Microbiology & Immunology, University of North Carolina, Chapel Hill, NC 27599-7290, USA. bourret@med.unc.edu
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Archaea / physiology
Archaeal Proteins* / chemistry,  genetics,  metabolism
Bacteria / growth & development
Bacterial Proteins* / chemistry,  genetics,  metabolism
Gene Expression Regulation, Archaeal*
Gene Expression Regulation, Bacterial*
Phosphorylation
Signal Transduction*
Structure-Activity Relationship
Grant Support
ID/Acronym/Agency:
GM050860/GM/NIGMS NIH HHS; R01 GM050860-16/GM/NIGMS NIH HHS; R01 GM050860-17/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Archaeal Proteins; 0/Bacterial Proteins
Comments/Corrections

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