Document Detail


Recapitulation of genome-wide association studies on pulse pressure and mean arterial pressure in the Korean population.
MedLine Citation:
PMID:  22475680     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increased pulse pressure (PP) and decreased mean arterial pressure (MAP) are strong prognostic predictors of adverse cardiovascular events. Recently, the International Consortium for Blood Pressure Genome-Wide Association Studies (ICBP-GWAS) reported eight loci that influenced PP and MAP. The ICBP-GWAS examined 51 cohorts--comprising 122 671 individuals of European ancestry--and identified eight SNPs: five that governed PP and three that controlled MAP. Six of these loci were novel. To replicate these newly identified loci and examine genetic architecture of PP and MAP between European and Asian populations, we conducted a meta-analysis of the eight SNPs combining data from ICBP and general population-based Korean cohorts. Two SNPs (rs13002573 (FIGN) and rs871606 (CHIC2)) for PP and two SNPs (rs1446468 (FIGN) and rs319690 (MAP4)) for MAP were replicated in Koreans. Although our GWAS only found moderate association, we believe that the findings promote us to propose that a similar genetic architecture governs PP and MAP in Asians and Europeans. However, further studies will be needed to confirm the possibility using other Asian population.
Authors:
Kyung-Won Hong; Haesook Min; Byeong-Mun Heo; Seong Eun Joo; Sung Soo Kim; Yeonjung Kim
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-05
Journal Detail:
Title:  Journal of human genetics     Volume:  57     ISSN:  1435-232X     ISO Abbreviation:  J. Hum. Genet.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-27     Completed Date:  2012-11-07     Revised Date:  2013-06-20    
Medline Journal Info:
Nlm Unique ID:  9808008     Medline TA:  J Hum Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  391-3     Citation Subset:  IM    
Affiliation:
Division of Epidemiology and Health Index, Center for Genome Science, Korea Centers for Disease Control and Prevention, Chungcheongbuk-do, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Asian Continental Ancestry Group / genetics*
Blood Pressure / genetics*
Female
Gene Frequency
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study*
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Republic of Korea

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