| Recall of disclosed apolipoprotein E genotype and lifetime risk estimate for Alzheimer's disease: the REVEAL Study. | |
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MedLine Citation:
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PMID: 17172937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine whether individuals recall their apolipoprotein E genotype and numeric lifetime risk estimates after undergoing a risk assessment for Alzheimer's disease. METHODS: One-hundred and four participants underwent Alzheimer's disease risk assessment that included disclosure of apolipoprotein E genotype and a numeric lifetime risk estimate. RESULTS: At six weeks and one year post-disclosure, 59% and 48% of participants, respectively, recalled their lifetime risk estimate, and 69% and 63% recalled their apolipoprotein E genotype. Participants were more likely to remember their genotype than numeric lifetime risk estimate at one year (P < 0.05). Apolipoprotein E epsilon4-positive participants had better recall of their genotype at both time points (P < 0.05). Participants were more likely to recall whether they carried the "risk-enhancing form of apolipoprotein E" than their specific genotype (P < 0.05). CONCLUSIONS: These data suggest that apolipoprotein E genotype, especially the presence of an epsilon4 allele, is more memorable than a numeric risk estimate for Alzheimer's disease. Participants recalled genotype information in a more simplified, binary form. Health professionals testing for complex disorders such as Alzheimer's disease must find an appropriate balance between communicating risk in an understandable format and addressing the probabilistic nature of the information. |
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Authors:
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Susan LaRusse Eckert; Heather Katzen; J Scott Roberts; Melissa Barber; Lisa D Ravdin; Norman R Relkin; Peter J Whitehouse; Robert C Green |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Genetics in medicine : official journal of the American College of Medical Genetics Volume: 8 ISSN: 1098-3600 ISO Abbreviation: Genet. Med. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-18 Completed Date: 2007-03-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9815831 Medline TA: Genet Med Country: United States |
Other Details:
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Languages: eng Pagination: 746-51 Citation Subset: IM |
Affiliation:
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Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alzheimer Disease / genetics, psychology* Apolipoproteins E / genetics* Disclosure* Female Genotype Humans Interviews as Topic Male Mental Recall* Middle Aged Risk Assessment |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR00533/RR/NCRR NIH HHS; P30 AG13846/AG/NIA NIH HHS; R01 HG/AG 02213/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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