| RecDraw: a software package for the representation of HIV-1 recombinant structures. | |
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MedLine Citation:
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PMID: 20961275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The crucial role of recombination in HIV-1 biology is being increasingly recognized. In vitro studies have shown that up to 30 strand-transfer events may occur per viral replication cycle. Thus, recombination may surpass mutation as a major mechanism driving HIV-1 evolution. Currently, recombinant strains comprise 37% of the full-genome HIV-1 sequence database, including sequences representing 47 Circulating Recombinant Forms (CRFs) and more than 250 different Unique Recombinant Forms (URFs). Mapping of recombination breakpoints helps establish relationships among strains that are related by descent, such as CRF07_BC and CRF08_BC in China, and sheds light on their origin and epidemic spread. Additionally, unrelated recombinants sharing common breakpoints may reflect recombination hotspots within the viral genome. Here we present a software tool, RecDraw, for the graphical representation and efficient comparison of recombinant HIV-1 structures and breakpoints. RecDraw is a platform-flexible, Java stand-alone application available through http://www.hivresearch.org/research.php?ServiceID = 5&SubServiceID = 6 . |
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Authors:
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Gustavo H Kijak; Sodsai Tovanabutra; Chris Beyrer; Eric E Sanders-Buell; Miguel A Arroyo; Merlin L Robb; Nelson L Michael; Francine E McCutchan; Jerome H Kim |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-10-21 |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: 26 ISSN: 1931-8405 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: 2011-03-15 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: United States |
Other Details:
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Languages: eng Pagination: 1317-21 Citation Subset: IM; X |
Affiliation:
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US Military HIV Research Program, Rockville, Maryland 20850, USA. gkijak@hivresearch.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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China Evolution, Molecular HIV Infections / virology* HIV-1 / genetics*, isolation & purification Humans Molecular Epidemiology / methods Recombination, Genetic* Software* Virology / methods* |
| Grant Support | |
ID/Acronym/Agency:
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YD1 AI2642-12/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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