Document Detail

Rebound phenomenon to systemic corticosteroid in atopic dermatitis.
MedLine Citation:
PMID:  16371217     Owner:  NLM     Status:  MEDLINE    
Three patients with atopic dermatitis, one boy and two girls, aged between 6 and 17 years, presented eczematous skin, pruritus, scarifications, lichenification and a family history of atopy. During exacerbations, the patients sought emergency care and were prescribed oral corticosteroids for a period of approximately 15 days. Initially, the patients improved but after cessation of therapy or dose reduction, marked worsening occurred with the development of lesions with extreme pruritus, several confluent lesions, scarification and intense exudates, as well as fever and dehydration. The patients' condition was so severe that two were admitted to the allergy unit. The medication was withdrawn and intravenous hydration was administered, together with hydrating skin creams and antihistamine therapy. In addition, weak topical corticosteroids were applied on the most severely affected areas. All three patients progressively improved. We conclude that the patients with atopic dermatitis described herein presented a rebound phenomenon after the use of corticosteroids. We believe that systemic corticosteroids may exacerbate the acute phase of atopic dermatitis, mediated by IgE, accentuating the Th2 pattern in these patients.
W C Neves Forte; J Mayumi Sumita; A Gianini Rodrigues; D Liuson; E Tanaka
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Allergologia et immunopathologia     Volume:  33     ISSN:  0301-0546     ISO Abbreviation:  Allergol Immunopathol (Madr)     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2005-12-22     Completed Date:  2006-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370073     Medline TA:  Allergol Immunopathol (Madr)     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  307-11     Citation Subset:  IM    
Immunology Section, Santa Casa Medical School and Hospital, São Paulo, Brazil.
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MeSH Terms
Acute Disease
Administration, Oral
Adrenal Cortex Hormones / administration & dosage,  adverse effects*,  therapeutic use
Anti-Allergic Agents / administration & dosage,  adverse effects*,  therapeutic use
Dermatitis, Atopic / drug therapy*,  immunology
Immunoglobulin E / immunology
Th2 Cells / immunology
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Allergic Agents; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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