Document Detail


Rebound increase of plasminogen activator inhibitor type I after cessation of thrombolytic treatment for acute myocardial infarction is independent of type of plasminogen activator used.
MedLine Citation:
PMID:  9474013     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma concentrations of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1), and D-dimer were investigated in 50 patients treated intravenously for acute myocardial infarction with either streptokinase (n = 23), urokinase (n = 17), or recombinant t-PA (rt-PA, n = 10). The fibrinolytic variables were measured by enzyme immunoassay on admission; 1, 2, 4, 6, 8, 12, and 24 h later; and then daily until day 7 after admission. In each subgroup of patients treated with different thrombolytic agents, PAI-1 increased significantly (P < 0.01) approximately 3 h after cessation of thrombolytic therapy. PAI-1 peak concentrations did not differ significantly (P = 0.82) among these three subgroups. t-PA and D-dimer did not differ significantly (P > 0.14) among subgroups except for higher t-PA in the rt-PA group attributable to detection of the therapeutically administered exogenous rt-PA by the t-PA assay. Our findings demonstrate a marked PAI-1 increase after thrombolytic therapy for acute myocardial infarction, which seems to be a common, drug-independent antifibrinolytic rebound phenomenon in response to thrombolytic treatment.
Authors:
N Genser; P Lechleitner; J Maier; F Dienstl; E Artner-Dworzak; B Puschendorf; J Mair
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  44     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-16     Completed Date:  1998-03-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  209-14     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Innsbruck, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Creatine Kinase / blood
Female
Fibrin Fibrinogen Degradation Products / analysis
Humans
Male
Middle Aged
Myocardial Infarction / drug therapy*
Myoglobin / blood
Plasminogen Activator Inhibitor 1 / metabolism*
Recombinant Proteins / therapeutic use
Streptokinase / therapeutic use
Thrombolytic Therapy*
Tissue Plasminogen Activator / blood,  therapeutic use*
Urokinase-Type Plasminogen Activator / therapeutic use
Chemical
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Myoglobin; 0/Plasminogen Activator Inhibitor 1; 0/Recombinant Proteins; 0/fibrin fragment D; EC 2.7.3.2/Creatine Kinase; EC 3.4.-/Streptokinase; EC 3.4.21.68/Tissue Plasminogen Activator; EC 3.4.21.73/Urokinase-Type Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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