| Rebound increase of PAI-1 following local intra-arterial rt-PA infusion, a possible cause of reocclusion. | |
| | |
MedLine Citation:
|
PMID: 8218853 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We studied systemic changes in the plasminogen activating system induced by local intra-arterial infusion of recombinant t-PA (rt-PA) in ten patients with arterial occlusion. The arterial infusion of rt-PA resulted in an immediate increase of t-PA activity and antigen in venous plasma. Concomitantly the plasma was depleted of PAI-1 activity with a moderate decrease of PAI-1 antigen, presumably due to immediate complexing of rt-PA by PAI-1 and gradual elimination of the rt-PA/PAI-1 complex from the circulation. Activation of plasminogen in the circulation was reflected by the occurrence of fibrinogen/fibrin degradation products. This rapid systemic activation of the fibrinolytic system at local intra-arterial administration of rt-PA might be due to the opening of small collaterals or backward flow through open arteries, allowing rt-PA to enter the general circulation. The disappearance of detectable PAI-1 activity during rt-PA infusion was followed by a rebound effect with a significant increase of PAI-1 antigen. As this increase may have contributed to the reocclusion which occurred in four patients, it might be advisable to replace heparin by rt-PA at a lower dosage in the immediate phase following rt-PA infusion. |
| | |
Authors:
|
B Astedt; B Casslén; I Lecander; L Nilsson; L Norgren |
Related Documents
:
|
2894423 - Postnatal development of the innervation and paraganglia in the porcine pulmonary arter... 21099583 - Targeted extracranial-intracranial bypass with intra-aneurysmal administration of indoc... 18839243 - Endovascular treatment of a brachiocephalic artery pseudoaneurysm secondary to biopsy a... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Volume: 4 ISSN: 0957-5235 ISO Abbreviation: Blood Coagul. Fibrinolysis Publication Date: 1993 Aug |
Date Detail:
|
Created Date: 1993-12-01 Completed Date: 1993-12-01 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9102551 Medline TA: Blood Coagul Fibrinolysis Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 563-7 Citation Subset: IM |
Affiliation:
|
Department of Gynaecology and Obstetrics, University of Lund, University Hospital, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Arterial Occlusive Diseases / drug therapy*, etiology Female Humans Infusions, Intra-Arterial Male Middle Aged Plasminogen Activator Inhibitor 1 / metabolism* Recombinant Proteins / administration & dosage Recurrence Tissue Plasminogen Activator / administration & dosage* |
| Chemical | |
Reg. No./Substance:
|
0/Plasminogen Activator Inhibitor 1; 0/Recombinant Proteins; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The clinical expression of hereditary protein C and protein S deficiency: a relation to clinical thr...
Next Document: Anticoagulant potential of synthetic and recombinant inhibitors of factor Xa and thrombin in vitro.