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Rebound hepatitis following withdrawal of immunosuppressive therapy in patients with chronic Hepatitis B viral infections.
MedLine Citation:
PMID:  15341768     Owner:  NLM     Status:  Publisher    
Background: Rebound hepatitis is a potentially life-threatening complication of withdrawal from immunosuppressive therapy in patients with chronic Hepatitis B viral (HBV) infections. Objectives: To document the incidence of rebound hepatitis and determine whether the hepatitis is associated with serologic evidence of immunological rebound or the appearance of specific mutations in the HBV genome. Methods: Serum cytokines (IL-6, IL-10, TNF-alpha and INF-gamma) were documented by enzyme linked immunoassays and previously described HBV mutants (surface, core, pre-core and basal core promoter) by signal probe hybridization analysis in chronic HBV carriers treated with either 6 weeks of prednisone followed by 6 weeks of acyclovir (PR/AC, n = 20) or placebo/placebo (PL/PL, n = 20). Results: Rebound hepatitis (serum ALT > 2X baseline) occurred in 6/20 (30%) PR/AC patients versus 2/20 (10%) PL/PL recipients (P = 0.24). Serum cytokine levels were similar in those who developed rebound hepatitis compared to those who did not. HBV mutants were absent prior to and during treatment but developed in the follow-up period in three patients. All three patients were PR/AC recipients and in each case, the HBV mutation was in the basal core promoter gene. In two of the three patients, the mutant appeared just prior to the onset of rebound hepatitis while in the third, rebound hepatitis did not occur. Conclusions: The results of this study indicate an association exists between some cases of rebound hepatitis and the development of HBV mutants.
G.Y. Minuk; J. Rempel; P. Wong; M. Zhang; S. Wong; W.W.S. Wong; A. Meyers; J. Uhanova
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Publication Detail:
Journal Detail:
Title:  Hepatology research : the official journal of the Japan Society of Hepatology     Volume:  30     ISSN:  -     ISO Abbreviation:  Hepatol. Res.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-Sep-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9711801     Medline TA:  Hepatol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  4-10     Citation Subset:  -    
Section of Hepatology, Department of Medicine, University of Manitoba, John Buhler Research Centre 803F-715 McDermot Avenue Winnipeg, Man., Canada R3E 3P4.
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