Document Detail


Rebound alkalosis and persistent lactate: multinuclear (1H, 13C, 31P) NMR spectroscopic studies in rats.
MedLine Citation:
PMID:  2062245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intracellular pH levels of infarcted brain determined by phosphorus-31 nuclear magnetic resonance (NMR) spectroscopy disclosed a notable phenomenon. The acidotic brain pH seen in the acute stage of infarction was observed to rebound into the alkalotic range in the subacute phase before returning to the normal range in the chronic phase. This "rebound alkalosis" which was usually observed between the 24th and the 48th hour after experimental induction of infarction in rats was accompanied by significant lactate levels as detected by proton NMR spectroscopy. Analysis of the satellite methyl resonance of 13C-lactate using high-resolution proton NMR spectroscopy after 13C-glucose infusion indicated that no lactate was produced in the subacute phase of infarction and that the lactate detected during this phase must have been generated prior to this phase of infarction.
Authors:
T Nakada; K Houkin; K Hida; I L Kwee
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  18     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-08-02     Completed Date:  1991-08-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-14     Citation Subset:  IM    
Affiliation:
Neurochemistry Research Laboratory, Department of Veterans Affairs Medical Center, Martinez, California 94553.
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MeSH Terms
Descriptor/Qualifier:
Alkalosis / diagnosis*
Animals
Brain / metabolism*,  pathology
Cerebral Infarction / diagnosis*,  metabolism
Hydrogen-Ion Concentration
Lactates / metabolism*
Lactic Acid
Magnetic Resonance Spectroscopy / diagnostic use
Male
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
GM 37197/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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