Document Detail

Rebleeding from a vertebral artery dissecting aneurysm after endovascular internal trapping: adverse effect of intrathecal urokinase injection or incomplete occlusion?-case report-.
MedLine Citation:
PMID:  20035136     Owner:  NLM     Status:  MEDLINE    
A 67-year-old woman suffered rebleeding from a ruptured vertebral artery dissecting aneurysm after endovascular internal trapping. The dissecting aneurysm was initially successfully occluded with the affected vertebral artery using detachable coils. However, rebleeding from the aneurysm occurred on the next day. The rebleeding may have resulted from the thrombolytic effect of urokinase, which was injected intrathecally 3 hours before rebleeding occurred, or the relatively loose coil packing of the aneurysm. This case indicates the potential risk of intrathecal use of thrombolytic agents and the importance of complete tight coil packing of the whole dissected site in the treatment of ruptured vertebral artery dissecting aneurysms.
Kenji Sugiu; Koji Tokunaga; Shigeki Ono; Ayumi Nishida; Isao Date
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurologia medico-chirurgica     Volume:  49     ISSN:  1349-8029     ISO Abbreviation:  Neurol. Med. Chir. (Tokyo)     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-25     Completed Date:  2010-03-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400775     Medline TA:  Neurol Med Chir (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  597-600     Citation Subset:  IM    
Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.
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MeSH Terms
Cerebral Angiography
Embolization, Therapeutic / adverse effects*,  instrumentation,  methods
Fibrinolytic Agents / adverse effects
Iatrogenic Disease / prevention & control
Injections, Spinal / adverse effects
Intracranial Thrombosis / drug therapy,  prevention & control
Postoperative Complications / etiology*,  pathology,  physiopathology
Prosthesis Implantation / adverse effects*,  instrumentation,  methods
Recurrence / prevention & control
Subarachnoid Hemorrhage / chemically induced*,  pathology,  radiography
Urokinase-Type Plasminogen Activator / adverse effects*
Vertebral Artery / drug effects,  pathology,  radiography
Vertebral Artery Dissection / complications,  radiography,  surgery*
Reg. No./Substance:
0/Fibrinolytic Agents; EC Plasminogen Activator

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