Document Detail

The Reb1-homologue Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast.
MedLine Citation:
PMID:  22805593     Owner:  NLM     Status:  MEDLINE    
Several DNA cis-elements and trans-acting factors were described to be involved in transcription termination and to release the elongating RNA polymerases from their templates. Different models for the molecular mechanism of transcription termination have been suggested for eukaryotic RNA polymerase I (Pol I) from results of in vitro and in vivo experiments. To analyse the molecular requirements for yeast RNA Pol I termination, an in vivo approach was used in which efficient termination resulted in growth inhibition. This led to the identification of a Myb-like protein, Ydr026c, as bona fide termination factor, now designated Nsi1 (NTS1 silencing protein 1), since it was very recently described as silencing factor of ribosomal DNA. Possible Nsi1 functions in regard to the mechanism of transcription termination are discussed.
Alarich Reiter; Stephan Hamperl; Hannah Seitz; Philipp Merkl; Jorge Perez-Fernandez; Lydia Williams; Jochen Gerber; Attila Németh; Isabelle Léger; Olivier Gadal; Philipp Milkereit; Joachim Griesenbeck; Herbert Tschochner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-17
Journal Detail:
Title:  The EMBO journal     Volume:  31     ISSN:  1460-2075     ISO Abbreviation:  EMBO J.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-15     Completed Date:  2012-10-23     Revised Date:  2013-08-18    
Medline Journal Info:
Nlm Unique ID:  8208664     Medline TA:  EMBO J     Country:  England    
Other Details:
Languages:  eng     Pagination:  3480-93     Citation Subset:  IM    
Universität Regensburg, Biochemie-Zentrum Regensburg (BZR), Lehrstuhl Biochemie III, Regensburg, Germany.
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MeSH Terms
Amino Acid Sequence
DNA-Binding Proteins / metabolism*
Molecular Sequence Data
RNA Polymerase I / metabolism*
Saccharomyces cerevisiae / enzymology,  growth & development,  physiology*
Saccharomyces cerevisiae Proteins / metabolism*
Sequence Homology, Amino Acid
Transcription, Genetic*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Nsi1 protein, S cerevisiae; 0/Saccharomyces cerevisiae Proteins; EC 2.7.7.-/RNA Polymerase I

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