Document Detail

Reassessment of the role of methane production between irritable bowel syndrome and functional constipation.
MedLine Citation:
PMID:  22720304     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND ANDAIMS: Modifications of intestinal gas due to changes in microbiota may produce different symptoms. Our aim was to assess whether different patterns of hydrogen (H2) and methane (CH4) excretion were related to some intestinal disturbances. METHODS. Six hundred and twenty-nine consecutive patients underwent a 50g-glucose breath test (GBT) on account of intestinal symptoms, which were evaluated by means of a questionnaire. "H2-producers" and "CH4-producers" were defined as with the presence of H2 peak >12ppm more than the basal sample and mean CH4 excretion of 2ppm, respectively. Forty healthy subjects were studied as controls. RESULTS. A small intestinal bacterial overgrowth was found in 45 cases (7.2%) and was associated with older age (p=0.0122). Methane production occurred in 32.3% of the study population. Methane excretion was strictly related to chronic constipation (p<0.001). Median CH4 excretion was higher in constipated patients compared with patients with normal daily stools (p=0.0406) and even more with patients complaining of diarrhea (p=0.0011). Different criteria for defining "methane-producers" provided similar results. Mean methane excretion of "methane producers" was 30.3ppm in functional constipation and 21.5ppm in constipation-irritable bowel syndrome (C-IBS) (p=0.0458). CONCLUSIONS. Methane excretion is clearly associated with alterations in intestinal motility, particularly favouring those with constipation. Mean methane excretion was higher in subjects suffering from functional constipation than C-IBS. Mean methane excretion higher or equal to 2ppm appears to be an appropriate term to define "methane-producers".
Manuele Furnari; Edoardo Savarino; Luca Bruzzone; Alessandro Moscatelli; Lorenzo Gemignani; Edoardo G Gianini; Patrizia Zentilin; Pietro Dulbecco; Vincenzo Savarino
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gastrointestinal and liver diseases : JGLD     Volume:  21     ISSN:  1842-1121     ISO Abbreviation:  J Gastrointestin Liver Dis     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101272825     Medline TA:  J Gastrointestin Liver Dis     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  157-63     Citation Subset:  IM    
Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy; Email:
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