| Reassessment of diagnostic criteria in cutaneous lymphocytic infiltrates. | |
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MedLine Citation:
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PMID: 15543371 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Non-specific lymphocytic infiltrates of the skin pose difficulties in daily practice in pathology. There is still a lack of pathognomonic signs for the differential diagnosis between benign and malignant lymphocytic infiltrates. OBJECTIVE: To evaluate the morphological and immunohistochemical profile of lymphocytic infiltrations of the skin according to clinical outcome. TYPE OF STUDY: Retrospective; histopathological and immunohistochemical analysis. SETTING: Referral center, university hospital. SAMPLE: 28 cases of lymphocytic infiltrates of difficult differential diagnosis selected from the records. MAIN MEASUREMENTS: Eighteen histological variables and the immunophenotypic profile were assessed using the CD4, CD8, CD3, CD20 and CD30 lymphoid markers and compared to subsequent follow-up. RESULTS: The most common diagnoses were: initial mycosis fungoides (eight cases) and drug reactions (five cases). Single morphological variables did not discriminate between benign and malignant infiltrates except for the presence of Pautrier-Darier's microabscesses, which were found only in mycosis fungoides (p = 0.015). Patterns of superficial and deep infiltration (p = 0.037) and also the presence of eosinophils (p = 0.0207) were more frequently found in benign lymphocytic infiltrates. Immunohistochemical profile of T-cell subsets showed overlap between benign and malignant infiltrates with a predominance of CD4-positive (helper) lymphocytes in the majority of cases. CONCLUSIONS: A combination of clinical and histological features remains the most reliable approach for establishing a definite diagnosis in cases of lymphoid skin infiltrates. |
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Authors:
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Ana Cristina Cotta; Maria Letícia Cintra; Elemir Macedo de Souza; Luis Alberto Magna; José Vassallo |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-11-09 |
Journal Detail:
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Title: São Paulo medical journal = Revista paulista de medicina Volume: 122 ISSN: 1516-3180 ISO Abbreviation: Sao Paulo Med J Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-11-15 Completed Date: 2005-04-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100897261 Medline TA: Sao Paulo Med J Country: Brazil |
Other Details:
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Languages: eng Pagination: 161-5 Citation Subset: IM |
Affiliation:
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Department of Pathology, School of Medical Sciences, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD
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analysis CD4-CD8 Ratio Chi-Square Distribution Diagnosis, Differential Follow-Up Studies Humans Mycosis Fungoides / pathology* Retrospective Studies Skin Neoplasms / pathology* Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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