Document Detail

Reassessing triglyceride synthesis in adipose tissue.
MedLine Citation:
PMID:  18929494     Owner:  NLM     Status:  MEDLINE    
The synthesis and breakdown of triglycerides in adipose tissue and muscle is a crucial element of energy metabolism because it ensures that adequate fuel is available during starvation. Triglyceride turnover determines the availability of fatty acids for utilization by mammalian tissues, and any dysfunction in this process can lead to alterations in glucose metabolism, insulin resistance and type 2 diabetes. Our understanding of the reactions involved in triglyceride synthesis is currently being reassessed, primarily because of the recently identified role that re-esterification of fatty acids plays in triglyceride deposition and, thus, in controlling fatty-acid availability. Here, we review recent information on triglyceride synthesis and introduce the pathway of glyceroneogenesis as an important and highly regulated source of glyceride-glycerol in adipose tissue.
Colleen Nye; Jaeyeon Kim; Satish C Kalhan; Richard W Hanson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-10-15
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  19     ISSN:  1043-2760     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-17     Completed Date:  2009-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  356-61     Citation Subset:  IM    
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106-3549, USA.
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MeSH Terms
Adipose Tissue / metabolism*
Fatty Acids / metabolism
Glycerol / metabolism
Glycolysis / physiology
Lipid Metabolism / physiology
Liver / metabolism
Models, Biological
Triglycerides / biosynthesis*
Grant Support
Reg. No./Substance:
0/Fatty Acids; 0/Triglycerides; 56-81-5/Glycerol

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