| Reassessing the diagnostic yield of saturation biopsy of the prostate. | |
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MedLine Citation:
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PMID: 17997028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Prostate biopsy remains the gold standard for detection of prostate cancer (PCa). This study was performed to determine whether saturation biopsy (>or= 24 cores) detects more prostate cancer than a standard 12-18 core office biopsy technique. METHODS: We conducted a nonrandomized cohort study of a consecutive series of prostate biopsies. The primary outcome assessed by both univariate and multivariate analysis was the detection of PCa, whereas the secondary outcomes of HGPIN (high-grade prostatic intraepithelial neoplasia) and ASAP (atypical small acinar proliferation) were also analyzed. RESULTS: From September 2005 to June 2006, a total of 469 patients undergoing prostate biopsy were included in this study. A standard office prostate biopsy was performed in 301 men, whereas 168 underwent a saturation biopsy. Age, body mass index (BMI), prostate volume, and family history of PCa were similar. However, patients in the saturation biopsy cohort were more likely to have had prior biopsies, higher prebiopsy PSA, longer PSA doubling times, and to carry more frequent diagnoses of HGPIN or ASAP (all p<0.05). After adjusting for covariates, saturation biopsy did not detect more abnormal pathology than standard office prostate biopsy, including PCa (OR, 1.2; p=0.339), HGPIN (OR, 1.4; p=0.368), or ASAP (OR, 2.2; p=0.201). CONCLUSIONS: Saturation biopsy does not appear to detect more abnormal prostate pathology than standard office biopsy of the prostate. This procedure may be associated with increased cost and patient morbidity. |
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Authors:
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Richard A Ashley; Brant A Inman; Jonathan C Routh; Lance A Mynderse; Matthew T Gettman; Michael L Blute |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-11-05 |
Journal Detail:
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Title: European urology Volume: 53 ISSN: 0302-2838 ISO Abbreviation: Eur. Urol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-02 Completed Date: 2008-09-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7512719 Medline TA: Eur Urol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 976-81 Citation Subset: IM |
Affiliation:
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Department of Urology, Mayo Clinic, Rochester, MN, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
/
blood,
diagnosis* Aged Biopsy / methods* Diagnosis, Differential Follow-Up Studies Humans Male Middle Aged Prospective Studies Prostate / pathology* Prostate-Specific Antigen / blood Prostatic Neoplasms / blood, diagnosis* Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.77/Prostate-Specific Antigen |
| Comments/Corrections | |
Comment In:
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Eur Urol. 2008 May;53(5):982-3
[PMID:
17997023
]
Eur Urol. 2008 May;53(5):981-2 [PMID: 17997013 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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