Document Detail

Rearrangement of proximal 11q13 band in a CMML in acute transformation.
MedLine Citation:
PMID:  7643618     Owner:  NLM     Status:  MEDLINE    
Fluorescence in situ hybridization (FISH) was performed on bone marrow cells thought to contain a t(7;11)(p22;q13) from a patient with chronic myelomonocytic leukemia in transformation. FISH analysis using a panel of 10 probes previously mapped to 11q13 revealed a cytogenetically undetected complex rearrangement that involved chromosomes 7 and 11 as well as a chromosome 3 at band p24. Two distinct translocation breakpoints, both proximal to the BCL1 locus, were found in chromosome 11 that perforce separate it into three subregions. The two breakpoints appear distinct from the two previously described ones which involved the FAU and GSTP1 genes. Our observations add to the involvement of proximal 11q13 in myeloid malignancies.
A Courseaux; J Grosgeorge; G Garnier; C Larsson; N Ayraud; P Gaudray; S D Raynaud
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia     Volume:  9     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-20     Completed Date:  1995-09-20     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1313-7     Citation Subset:  IM    
CNRS URA 1462, Nice, France.
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MeSH Terms
Acute Disease
Chromosome Aberrations / pathology*
Chromosome Disorders
Chromosome Mapping
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 7
DNA Probes
In Situ Hybridization, Fluorescence
Leukemia, Myelomonocytic, Chronic / genetics,  pathology*
Translocation, Genetic
Reg. No./Substance:
0/DNA Probes

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