Document Detail


Rearrangement strategy for the synthesis of 2-aminoanilines.
MedLine Citation:
PMID:  20199033     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Treatment of N-aryl hydroxylamines with trichloroacetonitrile in the presence of imidazole provides a simple and effective method for the preparation of synthetically versatile 2-aminoanilines. Reactions proceed in DMF at 40 degrees C, providing the products in up to 86% isolated yield.
Authors:
Achim Porzelle; Michael D Woodrow; Nicholas C O Tomkinson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Organic letters     Volume:  12     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1492-5     Citation Subset:  IM    
Affiliation:
School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, CF10 3AT, UK.
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MeSH Terms
Descriptor/Qualifier:
Aniline Compounds / chemical synthesis*,  chemistry
Molecular Structure
Stereoisomerism
Chemical
Reg. No./Substance:
0/Aniline Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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