Document Detail

Rearrangement of HMGA2 in a case of infantile lipoblastoma without Plag1 alteration.
MedLine Citation:
PMID:  22223189     Owner:  NLM     Status:  Publisher    
Lipoblastoma is a rare benign adipocytic tumor that occurs usually in children. It can be difficult to distinguish a lipoblastoma from other lipogenic tumors. In such cases, the detection of a rearrangement of the PLAG1 gene by fluorescence in situ hybridization analysis is useful for characterizing a lipoblastoma. We present here a novel case of morphological infantile lipoblastoma showing a rearrangement of HMGA2 instead of the classical PLAG1 alteration. HMGA2 is the main target of clonal aberrations encountered in lipomas. This result supports the hypothesis that benign lipomatous tumors harboring PLAG1 or HMGA2 rearrangement could constitute a unique pathogenetic entity. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc.
Florence Pedeutour; Anne Deville; Henri Steyaert; Dominique Ranchere-Vince; Damien Ambrosetti; Nicolas Sirvent
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-6
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  -     ISSN:  1545-5017     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
University of Nice-Sophia-Antipolis, CNRS, UMR 6543, Nice, France; Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France.
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