Document Detail


Rearing on basal or high dietary NaCl modifies chorda tympani nerve responses in rats.
MedLine Citation:
PMID:  12419404     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two experiments were conducted to determine the influence of dietary NaCl level on the integrated responses of the chorda tympani (CT) nerve to salt stimulation alone and mixed with the sodium-channel blocker, amiloride hydrochloride. Five groups of adult male rats were reared on regular chow containing either basal 0.1%, intermediate 1.0%, or high 3.0% NaCl from conception to postnatal day (PD) 30 or from conception to adulthood. Adult rats reared from conception to adulthood on basal dietary NaCl demonstrated a reduction in the CT nerve response to NaCl due to a decrease in the amiloride sensitive transduction mechanism. However, the CT nerve responses of adult rats reared on basal dietary NaCl to PD30 and then switched to intermediate dietary NaCl were similar to those of rats reared for a lifetime on intermediate dietary NaCl. Similarly, the CT nerve responses to NaCl in animals reared on high dietary NaCl from conception to PD30 and then switched to an intermediate NaCl diet were comparable to animals reared on intermediate and basal dietary NaCl. However, we found that exposure to high dietary NaCl led to a greater amiloride inhibition of NaCl responses. Thus, there is critical association between dietary NaCl level over two different exposure periods and CT nerve responsiveness to NaCl specifically regarding the degree of amiloride inhibition.
Authors:
David W Pittman; Robert J Contreras
Related Documents :
3834774 - The development of the peripheral autonomic nervous system in relation to the gastro-in...
2479404 - Immunocytochemistry of neuron-specific proteins and neuropeptides in taste buds and ass...
10727734 - Myelination in the splenium of the corpus callosum in adult male and female rats.
15011124 - Combined application of human amniotic membrane wrapping and hyaluronic acid injection ...
7651584 - Effects of linalool on glutamatergic system in the rat cerebral cortex.
3427914 - Ganglioside composition of liver and kidney from rat after pentazocine treatment.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  77     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-06     Completed Date:  2003-04-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-89     Citation Subset:  IM    
Affiliation:
Department of Psychology, The Florida State University, Tallahassee, FL 32306-1270, USA. pittmandw@wofford.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amiloride / pharmacology
Animals
Chorda Tympani Nerve / drug effects*,  growth & development*
Diuretics / pharmacology
Electrophysiology
Facial Nerve / drug effects,  physiology
Female
Male
Potassium Chloride / pharmacology
Pregnancy
Rats
Rats, Sprague-Dawley
Sodium Chloride, Dietary / pharmacology*
Tongue / drug effects,  innervation
Grant Support
ID/Acronym/Agency:
DC-00044/DC/NIDCD NIH HHS; DC-02641/DC/NIDCD NIH HHS; DC-04785/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Diuretics; 0/Sodium Chloride, Dietary; 2609-46-3/Amiloride; 7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fetal exposure to nicotine does not alter the core temperature response of 7- to 8-week-old rats to ...
Next Document:  Acute stress decreases inflammation at the site of infection. A role for nitric oxide.