Document Detail

Reappraisal of linoleic acid requirement of the young infant, with particular regard to use of modified cows' milk formulae.
MedLine Citation:
PMID:  569468     Owner:  NLM     Status:  MEDLINE    
Most infants in the UK are bottle fed with cows' milk formulae that are alleged to provide less than the minimum requirement for linoleic acid, i.e. 1% of the total dietary energy. 20 term infants fed solely on a modified cows' milk formula that provided 0.55% of the energy from linoleic acid were therefore examined for evidence of deficiency. Rates of growth in length and weight, measured during the first 3 months of life, were identical with those of 20 wholly breast-fed infants. Voluntary food intakes (kcal/kg per day) followed the normal pattern. The fatty acid composition of the plasma lipids showed changes characteristic of a low intake of linoleic acid, but triene:tetraene ratios did not indicate a deficiency state, and clinical signs of deficiency were not observed. These findings suggest that the requirement for linoleic acid is substantially less than was formerly believed. The small amount of alpha-linolenic acid present in cows' milk may however exert a sparing effect on linoleic acid.
D J Naismith; S P Deeprose; G Supramaniam; M J Williams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  53     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1979-02-26     Completed Date:  1979-02-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  845-9     Citation Subset:  AIM; IM    
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MeSH Terms
Breast Feeding
Energy Metabolism
Fatty Acids / blood
Infant Food* / analysis
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Linoleic Acids* / analysis
Milk* / analysis
Nutritional Requirements
Reg. No./Substance:
0/Fatty Acids; 0/Linoleic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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