Document Detail


Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response.
MedLine Citation:
PMID:  21723576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Disseminated leishmaniasis (DL) is an emerging form of Leishmania braziliensis infection characterised by multiple cutaneous lesions on different parts of the body and a high rate of mucosal involvement. Systemic production of TNFα and IFNγ in DL patients is lower than in cutaneous leishmaniasis (CL) caused by L. braziliensis, which may account for parasite dissemination due to the decreased ability to control parasite growth. In this study, the systemic and in situ immune response of DL and CL patients was characterised through evaluation of chemokine and cytokine production. In situ evaluation showed similar production of IFNγ, TNFα, IL-10, transforming growth factor-beta (TGFβ), chemokine (C-C motif) ligand 2 (CCL2), CCL3, CCL11 and chemokine (C-X-C motif) ligand 10 (CXCL10) in papular and ulcerative lesions from DL as well as in ulcerated lesions from CL. Serum levels of CXCL9, a chemokine that attracts T-cells, was higher in serum from DL than from CL. These data indicate that a decrease in the type 1 immune response in peripheral blood of DL patients is due to attraction of Leishmania antigen-activated T-cells to the multiple cutaneous lesions. This may account for the absence of or few parasites in the lesions and for the development of ulcers similar to those observed in CL.
Authors:
Paulo R Machado; Maria Elisa A Rosa; Diego Costa; Moema Mignac; João S Silva; Albert Schriefer; Mauro M Teixeira; Olivia Bacellar; Edgar M Carvalho
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-07-02
Journal Detail:
Title:  Transactions of the Royal Society of Tropical Medicine and Hygiene     Volume:  105     ISSN:  1878-3503     ISO Abbreviation:  Trans. R. Soc. Trop. Med. Hyg.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-18     Completed Date:  2011-10-07     Revised Date:  2013-07-19    
Medline Journal Info:
Nlm Unique ID:  7506129     Medline TA:  Trans R Soc Trop Med Hyg     Country:  England    
Other Details:
Languages:  eng     Pagination:  438-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Serviço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Antigens, Protozoan / metabolism
Brazil / epidemiology
Chemokines / immunology*
Female
Gene Expression Regulation / genetics
Humans
Interferon-gamma / immunology*
Leishmania braziliensis / immunology*
Leishmaniasis, Cutaneous / epidemiology,  genetics,  immunology*,  pathology
Male
Skin Tests
Skin Ulcer / immunology*,  parasitology*
T-Lymphocytes / immunology
Tumor Necrosis Factor-alpha / immunology*
Grant Support
ID/Acronym/Agency:
AI-30639/AI/NIAID NIH HHS; P50 AI030639/AI/NIAID NIH HHS; P50 AI030639-18/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Protozoan; 0/Chemokines; 0/Tumor Necrosis Factor-alpha; 82115-62-6/Interferon-gamma
Comments/Corrections

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