Document Detail

Real-time tissue elastography for evaluation of hepatic fibrosis and portal hypertension in nonalcoholic fatty liver diseases.
MedLine Citation:
PMID:  22488593     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to prospectively measure liver stiffness with real-time tissue elastography in patients with nonalcoholic fatty liver diseases (NAFLD) and to compare the result with the clinical assessment of fibrosis using histological stage. One hundred and eighty-one prospectively enrolled patients underwent real-time tissue elastography, with the first 106 being analyzed as the training set and the remaining 75 being evaluated as the validation set. Hepatic and splenic elastic ratios were calculated and compared with stage of histological fibrosis. Portal hypertension (PH) was assessed. Real-time tissue elastography cut-off values by stage in the training set were 2.47 for F1, 2.67 for F2, 3.02 for F3, and 3.36 for F4. Using these cut-off values, the diagnostic accuracy of hepatic fibrosis in the validation set was 82.6%-96.0% in all stages. Only portal fibrosis correlated with the hepatic elastic ratio by multivariate analysis. The area under the receiver operating characteristic curve of elastic ratio better correlated than serum fibrosis markers in both early and advanced fibrosis stages. Patients with PH, defined by splenic elasticity, had early fibrosis. Patients with severe PH were found only in the group with cirrhosis. Conclusion: Real-time tissue elastography is useful in evaluating hepatic fibrosis and PH in patients with NAFLD.
Hironori Ochi; Masashi Hirooka; Yohei Koizumi; Teruki Miyake; Yoshio Tokumoto; Yoshiko Soga; Fujimasa Tada; Masanori Abe; Yoichi Hiasa; Morikazu Onji
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-13
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  56     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-05     Completed Date:  2013-01-17     Revised Date:  2013-09-19    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1271-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine, Ehime, Japan.
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MeSH Terms
Analysis of Variance
Biopsy, Needle
Cohort Studies
Confidence Intervals
Elasticity Imaging Techniques / methods*
Evaluation Studies as Topic
Fatty Liver / complications,  pathology,  ultrasonography*
Hypertension, Portal / complications,  pathology,  ultrasonography*
Liver Cirrhosis / complications,  pathology,  ultrasonography*
Middle Aged
Multivariate Analysis
Odds Ratio
Predictive Value of Tests
Prospective Studies
Reproducibility of Results
Sensitivity and Specificity
Severity of Illness Index
Comment In:
Hepatology. 2013 Aug;58(2):834   [PMID:  23280434 ]
Hepatology. 2013 Aug;58(2):834-5   [PMID:  23280450 ]

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