| Real-time tissue elastography for evaluation of hepatic fibrosis and portal hypertension in non-alcoholic fatty liver diseases. | |
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MedLine Citation:
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PMID: 22488593 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The purpose of this study was to prospectively measure liver stiffness with real-time tissue elastography in patients with non-alcoholic fatty liver diseases (NAFLD), and to compare the result with clinical assessment of fibrosis using histological stage. One hundred and eighty-one prospectively enrolled patients underwent real-time tissue elastography, with the first 106 patients being analyzed as the training set and the remaining 75 being evaluated as the validation set. Hepatic and splenic elastic ratios were calculated and compared with stage of histological fibrosis. Portal hypertension was assessed. Real-time tissue elastography cutoff values by stage in the training set were 2.47 for F1, 2.67 for F2, 3.02 for F3 and 3.36 for F4. Using these cutoff values, the diagnostic accuracy of hepatic fibrosis in the validation set was 82.6% - 96.0% in all stages. Only portal fibrosis correlated with the hepatic elastic ratio by multivariate analysis. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve of elastic ratio better correlated than serum fibrosis markers in both early and advanced fibrosis stages. Patients with portal hypertension, defined by splenic elasticity, had early fibrosis. Patients with severe portal hypertension were found only in the cirrhotic group. Conclusion: Real-time tissue elastography is useful in evaluating hepatic fibrosis and portal hypertension in patients with NAFLD. (HEPATOLOGY 2012.). |
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Authors:
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Hironori Ochi; Masashi Hirooka; Yohei Koizumi; Eruki Miyake; Yoshio Tokumoto; Yoshiko Soga; Fujimasa Tada; Masanori Abe; Yoichi Hiasa; Morikazu Onji |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-5 |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: - ISSN: 1527-3350 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 American Association for the Study of Liver Diseases. |
Affiliation:
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Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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