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Real-time three-dimensional echocardiography integrated with diagnostic catheterization to derive left ventricular pressure-volume relations: a feasibility study.
MedLine Citation:
PMID:  23288888     Owner:  NLM     Status:  Publisher    
AIMS: We investigated the left ventricular (LV) myocardial contractility index-Emax using transoesophageal real-time three-dimensional echocardiography (RT3DE) combined with catheterization. METHODS AND RESULTS: Transoesophageal RT3DE (single beat, X7-2 X matrix, iE33, Philips) was used to obtain real-time LV volumes in pigs. Volumes were integrated with LV pressures from conductance catheterization (CC) with micromanometer to create RT3DE pressure-volume relations. At the same time, CC was used for measuring conventional pressure-volume relations that served as reference. The slope Emax was determined from RT3DE and CC end systolic pressure-volume relations. All measurements were made at rest and during dobutamine infusion. Six pigs were studied. At baseline, the mean ± SD (mmHg/mL) values were Emax-CC 1.86 ± 1.1 and Emax-RT3DE 1.78 ± 1.2 (P = 0.502). On dobutamine, mean Emax-CC was 3.43 ± 1.5 and Emax-RT3DE 3.60 ± 1.23 (P = 0.171). Bland-Altman analysis showed good agreements between the RT3DE and CC-derived Emax for measurements performed at baseline and on dobutamine. CONCLUSION: Emax can be determined from RT3DE integrated with catheterization-derived pressures. RT3DE is a promising method for enhancing clinical applicability of pressure-volume relations for assessment of myocardial contractility.
Shelby Kutty; Ling Li; Asif Padiyath; Sarah Nordmeyer; Paul Gribben; Shunji Gao; John Lof; Keshore R Bidasee; Felix Berger; David A Danford; Titus Kuehne
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-2
Journal Detail:
Title:  European heart journal cardiovascular Imaging     Volume:  -     ISSN:  2047-2412     ISO Abbreviation:  Eur Heart J Cardiovasc Imaging     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101573788     Medline TA:  Eur Heart J Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Pediatric Cardiology, University of Nebraska Medical Center and Children's Hospital and Medical Center, Omaha, NE, USA.
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