| Real time monitoring of biomaterial-mediated inflammatory responses via macrophage-targeting NIR nanoprobes. | |
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MedLine Citation:
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PMID: 21893338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Medical implant-mediated inflammatory responses, often involving high levels of macrophages, are typically determined by histological analyses. These methods however are time consuming and require many animals to monitor the kinetics of inflammatory reactions and to generate reproducible outcomes. Recent studies have shown that activated macrophages in inflamed tissue express high levels of folate receptor (FR). In this study, FR-targeting NIR nanoprobes were fabricated and then tested for their ability to detect and quantify the extent of biomaterial-mediated inflammatory responses in vivo. Indeed, FR-targeting nanoprobes preferentially accumulate on activated macrophage surfaces. When administered intravenously, we found that the FR-targeting nanoprobes distinctively gathered in the inflamed tissues and that a different extent of FR-targeting nanoprobe gathering could be found in tissues implanted with different types of biomaterials. Most importantly, we found that there was a good relationship between the extent of inflammatory reactions and the intensity of nanoprobe-associated NIR signal in tissue. Our results support that FR-targeting NIR nanoprobes can be used to monitor and quantify the extent of macrophage recruitment and the degree of an implants' biocompatibility in real time. |
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Authors:
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Jun Zhou; Yi-Ting Tsai; Hong Weng; David W Baker; Liping Tang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-09-03 |
Journal Detail:
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Title: Biomaterials Volume: 32 ISSN: 1878-5905 ISO Abbreviation: Biomaterials Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-10-10 Completed Date: 2012-02-03 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: England |
Other Details:
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Languages: eng Pagination: 9383-90 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3T3 Cells Acrylic Resins / chemistry Animals Biocompatible Materials / adverse effects* Folate Receptors, GPI-Anchored / metabolism Foreign-Body Reaction / pathology Implants, Experimental Inflammation / pathology* Infrared Rays* Lipopolysaccharides / pharmacology Macrophage Activation / drug effects Macrophages / drug effects, pathology* Mice Mice, Inbred BALB C Molecular Probes / metabolism* Nanoparticles / chemistry Particle Size Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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EB007271/EB/NIBIB NIH HHS; R01 EB007271-01A2/EB/NIBIB NIH HHS; R01 EB007271-01A2S1/EB/NIBIB NIH HHS; R01 EB007271-02/EB/NIBIB NIH HHS; R01 EB007271-03/EB/NIBIB NIH HHS; R01 EB007271-04/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acrylic Resins; 0/Biocompatible Materials; 0/Folate Receptors, GPI-Anchored; 0/Lipopolysaccharides; 0/Molecular Probes; 25189-55-3/poly-N-isopropylacrylamide |
| Comments/Corrections | |
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