| Real-time measurement of renal blood flow in healthy subjects using contrast-enhanced ultrasound. | |
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MedLine Citation:
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PMID: 19625375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Current methods for measuring renal blood flow (RBF) are time consuming and not widely available. Contrast-enhanced ultrasound (CEU) is a safe and noninvasive imaging technique suitable for assessment of tissue blood flow, which has been used clinically to assess myocardial blood flow. We tested the utility of CEU in monitoring changes in RBF in healthy volunteers. We utilized CEU to monitor the expected increase in RBF following a high protein meal in healthy adults. Renal cortical perfusion was assessed by CEU using low mechanical index (MI) power modulation Angio during continuous infusions of Definity. Following destruction of tissue microbubbles using ultrasound at a MI of 1.0, the rate of tissue replenishment with microbubbles and the plateau acoustic intensity (AI) were used to estimate the RBF velocity and cortical blood volume, respectively. Healthy adults (n = 19, mean age 26.6 yr) were enrolled. The A.beta parameter of CEU, representing mean RBF increased by 42.8%from a baseline of 17.05 +/- 6.23 to 23.60 +/- 6.76 dB/s 2 h after the ingestion of the high-protein meal (P = 0.002). Similarly, there was a 37.3%increase in the beta parameter, representing the geometric mean of blood velocity after the high protein meal (P < 0.001). The change in cortical blood volume was not significant (P = 0.89). Infusion time of Definity was 6.3 +/- 2.0 min. The ultrasound contrast agent was tolerated well with no serious adverse events. CEU is a fast, noninvasive, and practical imaging technique that may be useful for monitoring renal blood velocity, volume, and flow. |
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Authors:
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Kambiz Kalantarinia; J Todd Belcik; James T Patrie; Kevin Wei |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-07-22 |
Journal Detail:
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Title: American journal of physiology. Renal physiology Volume: 297 ISSN: 1522-1466 ISO Abbreviation: Am. J. Physiol. Renal Physiol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-29 Completed Date: 2009-10-27 Revised Date: 2011-05-09 |
Medline Journal Info:
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Nlm Unique ID: 100901990 Medline TA: Am J Physiol Renal Physiol Country: United States |
Other Details:
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Languages: eng Pagination: F1129-34 Citation Subset: IM |
Affiliation:
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Div. of Nephrology, Univ. of Virginia Health System, Box 800133, Charlottesville, VA 22908, USA. kk6c@virginia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Contrast Media / diagnostic use* Female Fluorocarbons / diagnostic use* Humans Kidney / ultrasonography* Male Middle Aged Renal Circulation* Ultrasonography, Doppler, Pulsed Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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DK-074616/DK/NIDDK NIH HHS; K23 DK074616-01A2/DK/NIDDK NIH HHS; M01-RR00847/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Definity; 0/Fluorocarbons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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