Document Detail


Real-time magnetic resonance imaging visualization and quantitative assessment of diffusion in the cerebral extracellular space of C6 glioma-bearing rats.
MedLine Citation:
PMID:  23562519     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Interstitial drug delivery is a promising technique for glioma treatment; however, suboptimal methodologies limit the ability to document the delivery of therapeutic agents. The present study employed magnetic resonance imaging for real-time visualization and quantitative assessment of drug diffusion in gliomas. Using gadolium-diethylenetriaminepentaacetic acid (Gd-DTPA) as a tracer, we considered diffusion in the agarose gel phantom as a reference and compared the diffusion and distribution patterns between the control group and C6 glioma-bearing rats after direct cerebral infusion. Our findings confirmed that Gd-DTPA diffusion was severely impaired in gliomas and presented in an anisotropic pattern in the caudate nucleus. The proposed method provides a new approach for the real-time monitoring of interstitial drug delivery and quantitative assessment of biophysical structural variations in diseased tissue.
Authors:
Kai Li; Hongbin Han; Kai Zhu; Kejia Lee; Bo Liu; Fugen Zhou; Yu Fu; Qingyuan He
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-2
Journal Detail:
Title:  Neuroscience letters     Volume:  -     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier Ireland Ltd.
Affiliation:
Department of Radiology, Peking University Third Hospital, Beijing, China; Beijing Key Lab of MRI Device and Technique, Beijing, China.
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