| Real-time high-resolution MRI for the assessment of gastric motility: pre- and postpharmacological stimuli. | |
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MedLine Citation:
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PMID: 15065169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the practicality of MRI using a new real-time sequence for the assessment of gastric motion, and quantify the effects of motility-modifying substances. MATERIALS AND METHODS: Six healthy volunteers ingested 400 mL of a high-calorie liquid nutrient. Two-dimensional real-time TrueFISP sequences were acquired for up to 30 minutes following the ingestion. The acquisition plane was chosen parallel to the axis of the gastric antrum. The examination was performed on three separate days with and without i.v. administration of 10 mg metoclopramide or 20 mg scopolamine. A motility index was calculated for each real-time data set. RESULTS: Delineation of the gastric lumen proved easy and robust. The intravenous application of motility-modifying agents resulted in significant changes in the motility index. The administration of metoclopramide resulted in an average increase of the index by a factor of 1.5, whereas the application of scopolamine led to a decrease of the index by a factor of 3.0. CONCLUSION: TrueFISP MRI performed well in depicting the gastric lumen and assessing gastric motility. Furthermore, we were able to evaluate and quantify the effect of motility-modifying agents. The noninvasive nature of MRI makes this imaging modality an attractive alternative to conventional invasive diagnostic tools for gastric motility disorders and monitoring of therapy. |
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Authors:
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Waleed Ajaj; Thomas Lauenstein; Nickolas Papanikolaou; Gerald Holtmann; Susanne C Goehde; Stefan G Ruehm; Joerg F Debatin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 19 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-05 Completed Date: 2004-06-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 453-8 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Wiley-Liss, Inc. |
Affiliation:
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Department of Diagnostic and Interventional Radiology, University Hospital Essen, Essen, Germany. Waleed.ajaj@uni-essen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Butylscopolammonium Bromide / administration & dosage, pharmacology* Contrast Media Energy Intake Female Gadolinium DTPA / diagnostic use Gastrointestinal Motility / drug effects* Humans Image Processing, Computer-Assisted / methods Injections, Intravenous Magnetic Resonance Imaging / methods* Male Metoclopramide / administration & dosage, pharmacology* Signal Processing, Computer-Assisted Stomach / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 149-64-4/Butylscopolammonium Bromide; 364-62-5/Metoclopramide; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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