Document Detail

Real-time dynamic frequency and shim correction for single-voxel magnetic resonance spectroscopy.
MedLine Citation:
PMID:  22851160     Owner:  NLM     Status:  MEDLINE    
Subject motion during brain magnetic resonance spectroscopy acquisitions generally reduces the magnetic field (B₀) homogeneity across the volume of interest or voxel. This is the case even if prospective motion correction ensures that the voxel follows the head. We introduce a novel method for rapidly mapping linear variations in B₀ across a small volume using two-dimensional excitations. The new field mapping technique was integrated into a prospectively motion-corrected single-voxel ¹H magnetic resonance spectroscopy sequence. Interference with the magnetic resonance spectroscopy measurement was negligible, and there was no penalty in scan time. Frequency shifts were also measured continuously, and both frequency and first-order shim corrections were applied in real time. Phantom experiments and in vivo studies demonstrated that the resulting motion- and shim-corrected sequence is able to mitigate line broadening and maintain spectral quality even in the presence of large-amplitude subject motion.
Brian Keating; Thomas Ernst
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-01-03
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  68     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-23     Completed Date:  2013-04-12     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1339-45     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
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MeSH Terms
Brain / anatomy & histology*
Brain Chemistry
Brain Mapping / methods*
Computer Systems
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Imaging, Three-Dimensional / methods*
Magnetic Resonance Spectroscopy / methods*
Reproducibility of Results
Sensitivity and Specificity
Grant Support
1R01 DA021146/DA/NIDA NIH HHS; G12 RR003061-21/RR/NCRR NIH HHS; K02-DA16991/DA/NIDA NIH HHS; R01 DA021146/DA/NIDA NIH HHS; R01 DA021146-05/DA/NIDA NIH HHS; U54 DA56883/DA/NIDA NIH HHS; U54 NS056883/NS/NINDS NIH HHS; U54 NS056883-05S1/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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