| Real-time Kt/V determination by ultraviolet absorbance in spent dialysate: technique validation. | |
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MedLine Citation:
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PMID: 20631678 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Real-time determination of Kt/V can be provided by monitoring ultraviolet absorbance of solutes in spent dialysate. This not only overcomes dependency on error-prone pre- and post-dialysis blood sampling; it circumvents inaccuracies associated with estimating the urea distribution volume and its high measurement frequency tightly reflects the course of the dialysis. Our study compared the ultraviolet-based spKt/V and eKt/V with the commonly used blood-based counterparts. A first study of 16 patients compared ultraviolet Kt/Vs against blood Kt/Vs obtained by using the 'gold standard' of serial blood samples. A second study included 18 patients and compared the ultraviolet and blood values under routine conditions. Both studies showed mean blood-based spKt/V and eKt/V values statistically indistinguishable from their ultraviolet-based counterparts. Hence, on-line monitoring of ultraviolet absorption of spent dialysate is applicable in routine hemodialysis allowing continuous measure of removed solutes from spent dialysate without disturbing the patient or treatment session. |
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Authors:
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Alex Castellarnau; Michael Werner; Roman Günthner; Marten Jakob |
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Publication Detail:
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Type: Journal Article Date: 2010-07-14 |
Journal Detail:
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Title: Kidney international Volume: 78 ISSN: 1523-1755 ISO Abbreviation: Kidney Int. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 920-5 Citation Subset: IM |
Affiliation:
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B Braun Avitum AG, Melsungen, Germany. alex.castellarnau@gmail.com |
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Descriptor/Qualifier:
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| Comments/Corrections | |
Comment In:
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Kidney Int. 2010 Nov;78(9):833-5
[PMID:
20948540
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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