| Real World Evaluation of Dual-Zone ICD and CRT-D Programming Compared to Single-Zone Programming: The ALTITUDE REDUCES Study. | |
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MedLine Citation:
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PMID: 21627705 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Tachycardia Detection, ICD, CRT-D Devices, Appropriate and Inappropriate Shock. Introduction: We evaluated the frequency of appropriate and inappropriate shocks and survival in patients using dual-zone programming versus single-zone programming. Methods and Results: For the ALTITUDE REDUCES study, patients were followed for 1.6 ± 1.1 years. The 12-month incidence of any shock was lower for dual-versus single-zone programmed detection at rates ≤170 bpm and between 170-200 bpm (P < 0.001). Appropriate shock rates at 1 year were also lower with dual-zone programming in these rate intervals (single zone 9.1%, 5.4%, P < 0.001, dual zone 6.7%, 4.7%, P < 0.02). There were no detectable differences between single- and dual-zone shock incidence at detection rates ≥ 200 bpm (P = 0.14). Inappropriate shock incidence was less with dual- versus single-zone detection at all detect rates <200 bpm, but not at rates ≥200 bpm (P < 0.001, P = 0.37). The lowest risk of appropriate and inappropriate shock was associated with dual-zone programming and detection rates ≥200 bpm (2.1%). Dual-zone detection was associated with more nonsustained and diverted therapy episodes but these patients did not have an increased risk of death compared to patients with single-zone programming. Patients programmed to low detection rate, single-zone detection and shock-only therapy also had the highest preshock mortality risk (P = 0.05). Conclusions: Shock incidence is lowest with either single- or dual-zone detection ≥200 bpm. For detection rates <200 bpm, dual-zone programming is associated with a reduction in the incidence of total shocks, appropriate shocks, and inappropriate shocks. (J Cardiovasc Electrophysiol, Vol, pp. 1-7). |
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Authors:
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F Roosevelt Gilliam; David L Hayes; John P Boehmer; John Day; Paul A Heidenreich; Milan Seth; Paul W Jones; Kenneth M Stein; Leslie A Saxon |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-31 |
Journal Detail:
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Title: Journal of cardiovascular electrophysiology Volume: - ISSN: 1540-8167 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-6-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010756 Medline TA: J Cardiovasc Electrophysiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Wiley Periodicals, Inc. |
Affiliation:
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Cardiology Associates of Northeast Arkansas, Jonesboro, Arkansas, USA Mayo Clinic, Rochester, Minnesota, USA Penn State College of Medicine, Hershey, Pennsylvania, USA Intermountain Heart Rhythm Specialists, Murray, Utah, USA Stanford University, Palo Alto, California, USA Boston Scientific Corporation, St. Paul, Minnesota, USA University of Southern California, Los Angeles, California, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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