| A real-time, telemetric method for continuous measurement of portal pressures. | |
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MedLine Citation:
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PMID: 20085839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability to longitudinally monitor portal and splanchnic pressures would greatly enhance the understanding of acute and chronic liver disease by helping to assess the immediate and long-term impact of therapeutic manipulations. However, a technique for measuring portal pressures in the ambulatory setting is not currently available. To overcome this difficulty, we utilized an approach that involved the implantation of a miniature telemetric device, equipped with a specially-designed pressure transmission catheter, into the spleen of an anesthetized mouse. Using this approach, portal pressures were measured continuously over 5 d in conscious, unrestrained animals, the availability of which will help facilitate studies of the portal circulation requiring long-term stability. |
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Authors:
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Jason Schwartz; Andreas Rohrwasser; Elaine Hillas; Jenny Hatch; John Sorensen; Timothy Gayowski; William Hutson; Jean-Marc Lalouel |
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Publication Detail:
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Type: Journal Article Date: 2009-11-10 |
Journal Detail:
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Title: The Journal of surgical research Volume: 159 ISSN: 1095-8673 ISO Abbreviation: J. Surg. Res. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-23 Completed Date: 2010-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: United States |
Other Details:
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Languages: eng Pagination: 618-21 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Utah, Salt Lake City, Utah 84132, USA. jason.schwartz@hsc.utah.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Chronic Disease Disease Models, Animal Infusion Pumps, Implantable Liver Diseases / physiopathology Male Mice Mice, Inbred C57BL Portal Pressure / physiology* Splanchnic Circulation / physiology* Telemetry / instrumentation, methods |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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