Document Detail

A real-time, telemetric method for continuous measurement of portal pressures.
MedLine Citation:
PMID:  20085839     Owner:  NLM     Status:  MEDLINE    
The ability to longitudinally monitor portal and splanchnic pressures would greatly enhance the understanding of acute and chronic liver disease by helping to assess the immediate and long-term impact of therapeutic manipulations. However, a technique for measuring portal pressures in the ambulatory setting is not currently available. To overcome this difficulty, we utilized an approach that involved the implantation of a miniature telemetric device, equipped with a specially-designed pressure transmission catheter, into the spleen of an anesthetized mouse. Using this approach, portal pressures were measured continuously over 5 d in conscious, unrestrained animals, the availability of which will help facilitate studies of the portal circulation requiring long-term stability.
Jason Schwartz; Andreas Rohrwasser; Elaine Hillas; Jenny Hatch; John Sorensen; Timothy Gayowski; William Hutson; Jean-Marc Lalouel
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Publication Detail:
Type:  Journal Article     Date:  2009-11-10
Journal Detail:
Title:  The Journal of surgical research     Volume:  159     ISSN:  1095-8673     ISO Abbreviation:  J. Surg. Res.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  618-21     Citation Subset:  IM    
Department of Surgery, University of Utah, Salt Lake City, Utah 84132, USA.
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MeSH Terms
Acute Disease
Chronic Disease
Disease Models, Animal
Infusion Pumps, Implantable
Liver Diseases / physiopathology
Mice, Inbred C57BL
Portal Pressure / physiology*
Splanchnic Circulation / physiology*
Telemetry / instrumentation,  methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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