Document Detail

Reactivity to mental stress and cold provocation during long-term treatment with metoprolol, propranolol or hydrochlorothiazide.
MedLine Citation:
PMID:  3475414     Owner:  NLM     Status:  MEDLINE    
In a study aimed at comparing the effects of beta-blockers and thiazide diuretics on responses to stressful provocations, 45 essential hypertensives (WHO I-II) were treated with either the selective beta-blocker metoprolol (METO), the non-selective beta-blocker propranolol (PROP) or hydrochlorothiazide (HTZ) for 6 months. Blood pressure, heart rate and plasma catecholamines were measured in connection with a mental stress test and a cold pressor test before and during therapy. All drugs reduced outpatient blood pressure similarly, but beta-blockade reduced blood pressure and heart rate levels more efficiently at rest and during stress in the laboratory. Heart rate reactivity to stress was reduced mostly by beta-blockade during mental stress. Blood pressure and sympatho-adrenal reactivity were unchanged by therapy. Stress reactivity failed to predict antihypertensive responses. The results suggest that beta-blockade may be more effective than diuretic treatment in reducing blood pressure levels and cardiac workload as assessed by the rate pressure product in stressful situations.
K Eliasson; T Kahan; B Hylander; P Hjemdahl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  4     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-09-16     Completed Date:  1987-09-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S263-5     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Catecholamines / blood
Cold Temperature / diagnostic use*
Hydrochlorothiazide / therapeutic use*
Hypertension / drug therapy*,  physiopathology,  psychology
Metoprolol / therapeutic use*
Propranolol / therapeutic use*
Psychological Tests
Stress, Psychological / physiopathology*
Time Factors
Reg. No./Substance:
0/Catecholamines; 37350-58-6/Metoprolol; 525-66-6/Propranolol; 58-93-5/Hydrochlorothiazide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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