Document Detail

Reactivity to autologous serum skin test and relationship with complement levels in chronic idiopathic urticaria and angio-oedema.
MedLine Citation:
PMID:  19094131     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A role for complement in autoantibody-mediated histamine release in urticaria has been suggested but not proven in vivo. Aim. To study serum complement levels in patients with chronic idiopathic urticaria (CIU) and to determine whether there was a relationship with autologous serum skin test (ASST) reactivity. METHODS: We recruited 35 patients with CIU. Complement (C3, C4) levels and ASST were measured in all patients; additional investigations were undertaken dependent on history and examination. RESULTS: Complement concentrations were outside the population reference intervals in 19/35 patients, with low C3 noted in 3/35 and low C4 in 18/35. Of 12 patients with a positive ASST, 7 had low complement levels, and 12/23 with a negative ASST had low complement levels. Patients with a positive ASST had a median C3 of 1.24 g/L (range 0.35-1.51) compared with a median of 1.25 g/L in those with a negative ASST (P = 0.36), and a median C4 of 0.20 g/L (range 0.185-0.452) in those with a positive ASST compared with 0.18 g/L in those with a negative ASST (P = 0.88). CONCLUSIONS: We conclude that both a reduction in C4 and positive ASST are common in CIU and although these immunological abnormalities often coexist, there is no clear relationship between them. Other components of the complement system may be worth exploring.
M Zamiri; C S Jury; R S Dawe; S O'Neill; W S Douglas
Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2008-12-15
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  34     ISSN:  1365-2230     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-10     Completed Date:  2009-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  587-90     Citation Subset:  IM    
Dermatology, Monklands Hospital, Airdrie, UK.
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MeSH Terms
Angioedema / immunology*
Complement C3 / analysis
Complement C4 / analysis
Complement System Proteins / analysis*
Middle Aged
Skin Tests / methods
Urticaria / immunology*
Young Adult
Reg. No./Substance:
0/Complement C3; 0/Complement C4; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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