Document Detail


Reactivity of isolated human right atria to norepinephrine in various disease states.
MedLine Citation:
PMID:  8527813     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The reactivity of isolated, electrically driven, right human atrial muscle to norepinephrine was studied in patients with coronary heart disease, with and without proximal right coronary artery occlusion, and in patients with mitral valve disease. The dose-effect curves for norepinephrine and ED50 doses for each group were compared. We found no difference in reactivity of atria from both coronary artery disease groups. The mitral valve disease group dose-effect curve was shifted to the right (potency ratio 3.98), and the maximal effect was significantly higher than in both coronary artery disease groups. We suggest that adrenoreceptor down regulation could account for observed ED50 difference. The difference in maximal responses could depend on more effective contraction mechanism in mitral valve disease myocardium. We conclude that occlusion of proximal right coronary artery does not necessarily mean ischaemia of right atrium and/or ischaemia does not change myocardium reactivity to norepinephrine.
Authors:
K S Gołba; M Deja; S Woś; R Bachowski; P Szałański; R Mrozek; Z S Herman
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  46     ISSN:  0867-5910     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-01-26     Completed Date:  1996-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  323-8     Citation Subset:  IM    
Affiliation:
II Department of Cardiac Surgery, Silesian Heart Center, Katowice, Poland.
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MeSH Terms
Descriptor/Qualifier:
Atrial Function, Right / drug effects*
Coronary Disease / drug therapy*
Dose-Response Relationship, Drug
Heart / drug effects*
Humans
Muscle Contraction
Norepinephrine / pharmacology*
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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