| Reactivity of coronary arteries in relation to serum magnesium levels in patients with ischaemic heart disease--a quantitative coronary angiographic study. | |
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MedLine Citation:
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PMID: 7669508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to evaluate the relationship between coronary vascular tone and serum magnesium concentration in patients with ischaemic heart disease. Thirty-seven patients were subjected to intracoronary injection of 200 micrograms nitroglycerine after discontinuation of anti-anginal medication for 24 h (group I, n = 23), except if they received calcium channel blockers (group II, n = 14). Coronary angiographic images were acquired before and 2 min after the nitroglycerine injection. Using quantitative coronary arteriography, the luminal diameter of one middle-sized non-stenotic coronary artery segment in each patient was measured before and after nitroglycerine injection, and the percentual increase was computed. In group I, coronary artery diameter changed from 3.0 +/- 0.7 to 3.5 +/- 0.6 mm (mean +/- SD), representing a 16.3 per cent increase. As expected, a more blunted response was observed in group II (from 3.5 +/- 0.8 to 3.7 +/- 1.0 mm, 6.5 per cent increase). However, neither of the groups displayed significant correlation between serum magnesium levels and the measured response to intracoronary nitroglycerine. In conclusion, this study fails to provide any correlation between serum magnesium levels within the normal physiological range and coronary vascular reactivity in patients with ischaemic heart disease. |
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Authors:
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W R Herzog; F J Materese; D Atar |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnesium research : official organ of the International Society for the Development of Research on Magnesium Volume: 8 ISSN: 0953-1424 ISO Abbreviation: Magnes Res Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-10-18 Completed Date: 1995-10-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8900948 Medline TA: Magnes Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 57-63 Citation Subset: IM |
Affiliation:
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University of Maryland Medical Center, Department of Medicine, Baltimore 21201, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Coronary Angiography* Coronary Vessels / drug effects, physiopathology* Female Humans Magnesium / blood* Male Middle Aged Myocardial Ischemia / physiopathology*, radiography Nitroglycerin / diagnostic use, pharmacology |
| Chemical | |
Reg. No./Substance:
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55-63-0/Nitroglycerin; 7439-95-4/Magnesium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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