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Reactivity of the 1,3-β-D-glucan assay during bacteraemia: limited evidence from a prospective study.
MedLine Citation:
PMID:  22594314     Owner:  NLM     Status:  Publisher    
There are discrepancies in the retrospective studies published in literature of whether or not bacteraemia could lead to false positivity of 1,3-β-D (BG) glucan assay. We performed, for the first time, a prospective study evaluating the role of bacterial bloodstream infection to the reactivity of BG assay. Twenty-six episodes of bacteraemia that occurred in high-risk haematological patients were included in our study. Consecutive BG levels >80 pg ml(-1) were required for test positivity. Only 2 of 26 patients were BG positive - both with IFDs. Thus, we prospectively did not prove bacteraemia as the source of cross reactivity of BG assay in haematological patients.
Zdenek Racil; Iva Kocmanova; Martina Toskova; Jana Winterova; Martina Lengerova; Shira Timilsina; Jiri Mayer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-18
Journal Detail:
Title:  Mycoses     Volume:  -     ISSN:  1439-0507     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8805008     Medline TA:  Mycoses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Verlag GmbH.
Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic Department of Microbiology, University Hospital Brno, Brno, Czech Republic CEITEC - Central European Institute of Technology, Masaryk University Brno, Brno, Czech Republic.
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