Document Detail

Reactive thrombocytosis after coronary bypass surgery. An important risk factor.
MedLine Citation:
PMID:  8519519     Owner:  NLM     Status:  MEDLINE    
Reactive thrombocytosis (RT) has earlier been reported to occur as a response to various situations and conditions, such as post-splenectomy, hematopoietic disorders, major trauma and operations, neoplasms and inflammations. In cardiac surgery the main interest has focused on thrombocytopenia that occurs after cardiopulmonary bypass (CPB) and the risk of postoperative bleeding, rather than the possibility of a late occurrence of RT as a risk factor for thrombotic complications after coronary artery bypass grafting (CABG). Between 1989 and 1992, on routine blood examinations we noticed a group of CABG patients (n = 297, Group II, 19.5%) that, 1 week after operation, showed thrombocytosis with significantly increased platelet count (521 +/- 96 x 10(3)/mm3) compared to patients with normal platelet counts (Group I, n = 1521, 185 +/- 125 x 10(3)/mm3); P < 0.001. Patient characteristics, coronary angiography findings, operative data and perioperative complications were analyzed for the two groups. There were significantly more patients with hyperlipidemia, smoking and previous myocardial infarction in Group II than in Group I; P < 0.05. Age, sex, clinical characteristics, angiography findings and operative data did not differ between the groups. There were no differences in postoperative bleeding or the need of transfusion between the groups. However, Group II (RT) patients had significantly more postoperative myocardial infarctions, 4.4% compared to 0.7% Group I; P < 0.001. Early symptomatic vein graft occlusion (0-7 days postoperatively) was not different between the groups, while there were significantly move late symptomatic vein graft occlusions (7-60 days postoperatively) in Group II (RT) 4.4% than in Group I 1.1%; P < 0.001.(ABSTRACT TRUNCATED AT 250 WORDS)
M Schmuziger; J T Christenson; J Maurice; F Simonet; V Velebit
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  9     ISSN:  1010-7940     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  1995  
Date Detail:
Created Date:  1996-01-24     Completed Date:  1996-01-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  393-7; discussion 397-8     Citation Subset:  IM    
Cardiovascular Surgery Unit, Hôpital de la Tour, Geneva, Switzerland.
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Coronary Artery Bypass / adverse effects*,  mortality
Middle Aged
Postoperative Complications
Risk Factors
Survival Rate
Thrombocytosis / etiology*,  mortality
Time Factors

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