Document Detail


Reactive and reparative myocardial fibrosis in arterial hypertension in the rat.
MedLine Citation:
PMID:  1423431     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Myocardial fibrosis is an important determinant of pathological hypertrophy. In two experimental models of arterial hypertension the purpose of the study was (a) to determine total collagen volume fraction and relative contribution of scarring and perivascular/interstitial fibrosis; and (b) to assess the effects of the aldosterone receptor antagonist spironolactone on these patterns of fibrosis. METHODS: 76 eight week old Sprague-Dawley rats weighing 180 to 200 g were used for the studies. Using videodensitometry total collagen volume fraction was separated into the various components for the left and right ventricles in the following experimental models: renovascular hypertension occurring following unilateral renal ischaemia; continuous aldosterone administration via osmotic minipumps with either high (AL) or low (ALLO) sodium diet; renovascular hypertension and AL after pretreatment and continuous treatment with either 20 or 200 mg.kg-1.d-1 subcutaneously of the competitive aldosterone receptor antagonist spironolactone. All groups were compared to age and sex matched controls. RESULTS: After eight weeks, systolic pressure was comparably increased in renovascular hypertension and AL and it remained raised with low dose spironolactone treatment in either model, but was normal with high dose spironolactone or low sodium diet. Left ventricular hypertrophy, expressed as a significant increase in left to right ventricular weight and left ventricle to body weight ratios, was present in renovascular hypertension, AL, and AL + low dose spironolactone compared to control (p < 0.005). In either ventricle: (1) the amount of interstitial/perivascular fibrosis and myocardial scarring was increased (p < 0.005) in renovascular hypertension and AL compared to control; (2) each was reduced (p < 0.005) with either dose of spironolactone; and (3) only scars were seen in ALLO. CONCLUSIONS: Myocardial fibrosis of either ventricle was comparable in renovascular hypertension and AL. Spironolactone was able largely to prevent the perivascular/interstitial fibrosis and scarring in either model irrespective of the development of left ventricular hypertrophy and arterial hypertension. Low sodium diet in hyperaldosteronism prevented hypertension and left ventricular hypertrophy, but not scarring. These findings suggest that a rise in plasma aldosterone, relative to sodium intake, may play a role in mediating collagen accumulation in the heart during the development of experimental arterial hypertension.
Authors:
C G Brilla; K T Weber
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  26     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-12-02     Completed Date:  1992-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  671-7     Citation Subset:  IM    
Affiliation:
Division of Cardiology, University of Missouri-Columbia 65212.
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MeSH Terms
Descriptor/Qualifier:
Aldosterone / blood,  pharmacology
Angiotensin II / blood
Animals
Cardiomegaly / blood,  metabolism,  pathology*
Collagen / metabolism
Disease Models, Animal
Fibrosis
Hypertension, Renovascular / blood,  metabolism,  pathology*
Male
Myocardium / metabolism,  pathology*
Rats
Rats, Sprague-Dawley
Sodium, Dietary / administration & dosage
Spironolactone / pharmacology
Chemical
Reg. No./Substance:
0/Sodium, Dietary; 11128-99-7/Angiotensin II; 52-01-7/Spironolactone; 52-39-1/Aldosterone; 9007-34-5/Collagen

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