| Reactive oxygen species and vascular remodelling in hypertension: still alive. | |
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MedLine Citation:
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PMID: 16971980 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reactive oxygen species (ROS) are reactive derivatives of O2 metabolism, including superoxide anion, hydrogen peroxide, hydroxyl radical and nitric oxide. All types of vascular cells produce ROS, primarily via cell membrane-associated NAD(P)H oxidase. Cardiovascular diseases, such as hypertension, are associated with increased ROS formation (oxidative stress). Oxidative excess in the vasculature reduces levels of the vasodilator nitric oxide, causes tissue injury, promotes protein oxidation and DNA damage, and induces proinflammatory responses. ROS are also important intracellular signalling molecules that regulate vascular function by modulating vascular cell contraction/dilation, migration, growth/apoptosis, and extracellular matrix protein turnover, which contribute to vascular remodelling. Interventions to decrease ROS bioavailability regress remodelling and reduce blood pressure in experimental hypertension. Such strategies may have therapeutic potential in cardiovascular diseases. |
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Authors:
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Shaoping Xu; Rhian M Touyz |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 22 ISSN: 0828-282X ISO Abbreviation: Can J Cardiol Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-14 Completed Date: 2006-10-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: Canada |
Other Details:
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Languages: eng Pagination: 947-51 Citation Subset: IM |
Affiliation:
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Kidney Research Center, Ottawa Health Research Institute, University of Ottawa, Ottawa, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Vessels
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metabolism,
physiopathology Endothelium, Vascular / metabolism, physiopathology Humans Hypertension / metabolism*, physiopathology Inflammation / metabolism, physiopathology Reactive Oxygen Species / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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