Document Detail

Reactive oxygen species and vascular remodelling in hypertension: still alive.
MedLine Citation:
PMID:  16971980     Owner:  NLM     Status:  MEDLINE    
Reactive oxygen species (ROS) are reactive derivatives of O2 metabolism, including superoxide anion, hydrogen peroxide, hydroxyl radical and nitric oxide. All types of vascular cells produce ROS, primarily via cell membrane-associated NAD(P)H oxidase. Cardiovascular diseases, such as hypertension, are associated with increased ROS formation (oxidative stress). Oxidative excess in the vasculature reduces levels of the vasodilator nitric oxide, causes tissue injury, promotes protein oxidation and DNA damage, and induces proinflammatory responses. ROS are also important intracellular signalling molecules that regulate vascular function by modulating vascular cell contraction/dilation, migration, growth/apoptosis, and extracellular matrix protein turnover, which contribute to vascular remodelling. Interventions to decrease ROS bioavailability regress remodelling and reduce blood pressure in experimental hypertension. Such strategies may have therapeutic potential in cardiovascular diseases.
Shaoping Xu; Rhian M Touyz
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  22     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-14     Completed Date:  2006-10-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  947-51     Citation Subset:  IM    
Kidney Research Center, Ottawa Health Research Institute, University of Ottawa, Ottawa, Canada.
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MeSH Terms
Blood Vessels / metabolism,  physiopathology
Endothelium, Vascular / metabolism,  physiopathology
Hypertension / metabolism*,  physiopathology
Inflammation / metabolism,  physiopathology
Reactive Oxygen Species / metabolism*
Reg. No./Substance:
0/Reactive Oxygen Species

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