Document Detail

Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation.
MedLine Citation:
PMID:  23146892     Owner:  NLM     Status:  MEDLINE    
Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR-199a and miR-125b target ERBB2 and/or ERBB3 in ovarian cancer cells, and demonstrate that ROS inhibit miR-199a and miR-125b expression through increasing the promoter methylation of the miR-199a and miR-125b genes by DNA methyltransferase 1. These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR-199a and miR-125b downregulation and DNA hypermethylation.
Jun He; Qing Xu; Yi Jing; Faton Agani; Xu Qian; Richard Carpenter; Qi Li; Xin-Ru Wang; Stephen S Peiper; Zhimin Lu; Ling-Zhi Liu; Bing-Hua Jiang
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-13
Journal Detail:
Title:  EMBO reports     Volume:  13     ISSN:  1469-3178     ISO Abbreviation:  EMBO Rep.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-05-30     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  1116-22     Citation Subset:  IM    
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MeSH Terms
Allantois / growth & development
Cell Line, Tumor / drug effects
DNA (Cytosine-5-)-Methyltransferase / metabolism
DNA Methylation / drug effects
Fluoresceins / chemistry,  pharmacology
Gene Expression Regulation, Neoplastic / drug effects
MicroRNAs* / genetics,  metabolism
Ovarian Neoplasms* / genetics,  metabolism
Promoter Regions, Genetic / drug effects
Reactive Oxygen Species* / chemistry,  metabolism
Receptor, erbB-2* / genetics,  metabolism
Receptor, erbB-3 / genetics*
Grant Support
Reg. No./Substance:
0/ERBB3 protein, human; 0/Fluoresceins; 0/MIRN125 microRNA, human; 0/MicroRNAs; 0/Reactive Oxygen Species; 0/mirn199 microRNA, human; 2044-85-1/diacetyldichlorofluorescein; EC (Cytosine-5-)-Methyltransferase; EC (cytosine-5-)-methyltransferase 1; EC protein, human; EC, erbB-2; EC, erbB-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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