| Reactive oxygen species, isotope effect, essential nutrients, and enhanced longevity. | |
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MedLine Citation:
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PMID: 17378752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A method is proposed that has the potential to lessen detrimental damages caused by reactive oxygen species (ROS) to proteins, nucleic acids, lipids, and other components in living cells. Typically, ROS oxidize substrates by a mechanism involving hydrogen abstraction in a rate-limiting step. The sites within these (bio)molecules susceptible to oxidation by ROS can thus be "protected " using heavier isotopes such as (2)H (D, deuterium) and (13)C (carbon-13). Ingestion of isotopically reinforced building blocks such as amino acids, lipids and components of nucleic acids and their subsequent incorporation into macromolecules would make these more stable to ROS courtesy of an isotope effect. The implications may include enhanced longevity and increased resistance to cancer and age-related diseases. |
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Authors:
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Mikhail S Shchepinov |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Rejuvenation research Volume: 10 ISSN: 1549-1684 ISO Abbreviation: Rejuvenation Res Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-23 Completed Date: 2007-07-26 Revised Date: 2007-09-11 |
Medline Journal Info:
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Nlm Unique ID: 101213381 Medline TA: Rejuvenation Res Country: United States |
Other Details:
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Languages: eng Pagination: 47-59 Citation Subset: IM |
Affiliation:
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Retrotope, Inc. Oxford, UK. misha@tridend.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Isotopes* Longevity / physiology* Nucleic Acids Oxidation-Reduction Reactive Nitrogen Species Reactive Oxygen Species* |
| Chemical | |
Reg. No./Substance:
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0/Isotopes; 0/Nucleic Acids; 0/Reactive Nitrogen Species; 0/Reactive Oxygen Species |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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