| Reactive oxygen species in melanoma and its therapeutic implications. | |
| | |
MedLine Citation:
|
PMID: 17992124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Oxidative phosphorylation in the mitochondria is an important energy-producing process for eukaryotic cells, but this process can also result in producing potentially cell-damaging side products. Oxygen is the final proton acceptor in this cascade of electron/proton transfer and results in harmless water. The electron transfer, however, is not completely efficient and results in the production of reactive oxygen species (ROS). Low amounts of these ROS are important for cellular-signalling pathways. Excessive ROS, however, can induce cell damage that can culminate in cell death. Therefore, the cell has developed an antioxidant network to scavenge excessively produced ROS. In general, the balance between the production and scavenging of ROS leads to homeostasis. Disturbance of this equilibrium can alter normal cellular processes; it often occurs in tumour cells. In this review, the role of ROS in cutaneous melanoma development and progression is described. Cutaneous melanoma arises from epidermal melanocytes in skin, which is a relatively hypoxic tissue. ROS are generated as a result of increased metabolism of transformed cells, immune reaction against the developing tumour, ultraviolet radiation, melanin production and an altered antioxidant system. Knowledge of the role of ROS in melanoma development and the mechanisms that alleviate oxidative stress can aid in the development of better antimelanoma therapies. |
| | |
Authors:
|
Hanneke G M Wittgen; Léon C L T van Kempen |
Related Documents
:
|
20164154 - Reactive oxygen species differently regulate renal tubular epithelial and interstitial ... 20228054 - Protection of cells in physiological oxygen tensions against dna damage-induced apoptosis. 17258074 - An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. 16668444 - Differential effects of elicitors on the viability of rice suspension cells. 2300074 - In vitro induction, expression and selection of thioguanine-resistant mutants with huma... 12499864 - Transient osmotic stress facilitates mutant huntingtin aggregation. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Melanoma research Volume: 17 ISSN: 0960-8931 ISO Abbreviation: Melanoma Res. Publication Date: 2007 Dec |
Date Detail:
|
Created Date: 2007-11-09 Completed Date: 2008-02-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9109623 Medline TA: Melanoma Res Country: England |
Other Details:
|
Languages: eng Pagination: 400-9 Citation Subset: IM |
Affiliation:
|
Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antioxidants / metabolism* Electron Transport Humans Melanins / biosynthesis* Melanoma / drug therapy*, immunology, metabolism*, secondary Mitochondria / metabolism* Oxidation-Reduction Oxidative Phosphorylation Oxidative Stress Reactive Oxygen Species / metabolism* Signal Transduction Skin Neoplasms / drug therapy, immunology, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Melanins; 0/Reactive Oxygen Species |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evidence and interdisciplinary consense-based German guidelines: diagnosis and surveillance of melan...
Next Document: Crime in the workplace, part 2.