Document Detail

Reactive oxygen species in cancer.
MedLine Citation:
PMID:  20370557     Owner:  NLM     Status:  MEDLINE    
Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers, where they promote many aspects of tumour development and progression. However, tumour cells also express increased levels of antioxidant proteins to detoxify from ROS, suggesting that a delicate balance of intracellular ROS levels is required for cancer cell function. Further, the radical generated, the location of its generation, as well as the local concentration is important for the cellular functions of ROS in cancer. A challenge for novel therapeutic strategies will be the fine tuning of intracellular ROS signalling to effectively deprive cells from ROS-induced tumour promoting events, towards tipping the balance to ROS-induced apoptotic signalling. Alternatively, therapeutic antioxidants may prevent early events in tumour development, where ROS are important. However, to effectively target cancer cells specific ROS-sensing signalling pathways that mediate the diverse stress-regulated cellular functions need to be identified. This review discusses the generation of ROS within tumour cells, their detoxification, their cellular effects, as well as the major signalling cascades they utilize, but also provides an outlook on their modulation in therapeutics.
Geou-Yarh Liou; Peter Storz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Free radical research     Volume:  44     ISSN:  1029-2470     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-09-16     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  479-96     Citation Subset:  IM    
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MeSH Terms
Neoplasms / metabolism*,  pathology,  therapy
Reactive Oxygen Species / metabolism*
Signal Transduction
Grant Support
CA135102/CA/NCI NIH HHS; P50 CA102701/CA/NCI NIH HHS; P50 CA102701/CA/NCI NIH HHS; R21 CA135102/CA/NCI NIH HHS
Reg. No./Substance:
0/Reactive Oxygen Species

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