Document Detail


Reactive oxygen species in cancer.
MedLine Citation:
PMID:  20370557     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers, where they promote many aspects of tumour development and progression. However, tumour cells also express increased levels of antioxidant proteins to detoxify from ROS, suggesting that a delicate balance of intracellular ROS levels is required for cancer cell function. Further, the radical generated, the location of its generation, as well as the local concentration is important for the cellular functions of ROS in cancer. A challenge for novel therapeutic strategies will be the fine tuning of intracellular ROS signalling to effectively deprive cells from ROS-induced tumour promoting events, towards tipping the balance to ROS-induced apoptotic signalling. Alternatively, therapeutic antioxidants may prevent early events in tumour development, where ROS are important. However, to effectively target cancer cells specific ROS-sensing signalling pathways that mediate the diverse stress-regulated cellular functions need to be identified. This review discusses the generation of ROS within tumour cells, their detoxification, their cellular effects, as well as the major signalling cascades they utilize, but also provides an outlook on their modulation in therapeutics.
Authors:
Geou-Yarh Liou; Peter Storz
Related Documents :
18948147 - Lysosomal involvement in cell death and cancer.
23046527 - The oncoprotein and stem cell renewal factor bmi1 associates with poor clinical outcome...
23477587 - Current adoptive immunotherapy in non-small cell lung cancer and potential influence of...
22285777 - Coping and psychological distress in young adults with advanced cancer.
18573807 - Asbestos fibre concentrations in the lungs of brake workers: another look.
6660717 - Ultraviolet light, cataracts, and spectacle wear.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Free radical research     Volume:  44     ISSN:  1029-2470     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-09-16     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  479-96     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Neoplasms / metabolism*,  pathology,  therapy
Reactive Oxygen Species / metabolism*
Signal Transduction
Grant Support
ID/Acronym/Agency:
CA135102/CA/NCI NIH HHS; P50 CA102701/CA/NCI NIH HHS; P50 CA102701/CA/NCI NIH HHS; P50 CA102701-07/CA/NCI NIH HHS; R21 CA135102/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Reactive Oxygen Species
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Silibinin induces the generation of nitric oxide in human breast cancer MCF-7 cells.
Next Document:  Specific oxidative stress profile associated with partial striatal dopaminergic depletion by 6-hydro...